Changes in the kidney structure in outbred and inbred male BALB/c mice were analyzed in the acute period after infection with influenza viruses A/H5N1 (10 MLD50; 10 days) and A/H1N1 (1 MLD50; 30 days). Antibodies to influenza viruses of both strains were most often expressed by endothelial cells of the glomeruli and arterioles and were rarely expressed by mesangiocytes and tubule epithelial cells. In the kidney, destructive processes induced by viruses and by ischemia due to massive blood vessel thrombosis. Mesangiocytes expressed factors, indicating that they could be qualified as M1 and M2 macrophages. Kidney destruction was more significant after infection of mice with the A/H5N1 virus, but in both experiments cell infiltrates were actually absent, probably due to blood vessel thrombosis and limited possibility of migration of mononuclear phagocytes and lymphocytes to the kidney.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Avtandilov GG. Medical Morphometry. Moscow, 2001. Russian.
Monastyrskaya EA, Lyamina SV, Malyshev IYu. M1 and M2 phenotypes of activated macrophages and their role in immune response and pathology. Patogenez. 2008;6(4):31-39. Russian.
Shkurupy VA, Kim LB, Kovner AV, Cherdantseva LA. Connective tissue and the problems of its pathological conditions. Byull. Sib. Med. 2017;16(4):75-85. Russian.
Anikina AG, Shkurupii VA, Potapova OV, Kovner AV, Shestopalov AM. Expression of profibrotic growth factors and their receptors by mouse lung macrophages and fibroblasts under conditions of acute viral inflammation in influenza A/H5N1 virus. Bull. Exp. Biol. Med. 2014;156(6):833-837.
Kovner AV, Anikina AG, Potapova OV, Sharkova TV, Cherdanceva LA, Shkurupy VA, Shestopalov AM. Structural and functional changes in pulmonary macrophages and lungs of mice infected with influenza virus A/H5N1 A/goose/Krasnoozerskoye/627/05. Bull. Exp. Biol. Med. 2012;153(2):229-232.
Potapova OV, Kovner AV, Anikina AG, Cherdantseva LA, Sharkova TV, Shkurupy VA, Vasil’eva EV, Shestopalov AM. Studies of Influenza A/H1N1 A/Tomsk/13/2010 virus topology during development of infectious process in mammals. Bull. Exp. Biol. Med. 2016;160(5):683-686.
Shatskaya EV, Kovner AV, Potapova OV, Cherdantseva LA, Shkurupy VA, Shestopalov AM. Study of SMAD-dependent signal pathway in the development of early pulmonary fibrosis in mice infected with influenza A/H1N1 virus. Bull. Exp. Biol. Med. 2017;162(5):647-649.
Viehmann SF, Böhner AMC, Kurts C, Brähler S. The multifaceted role of the renal mononuclear phagocyte system. Cell. Immunol. 2018. pii: S0008-8749(18)30180-1. doi: https://doi.org/10.1016/j.cellimm.2018.04.009.
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 166, No. 9, pp. 330-335, September, 2018
Rights and permissions
About this article
Cite this article
Shkurupy, V.A., Potapova, O.V., Mezhevalova, A.S. et al. Changes in the Structure of Mouse Kidney in the Acute Period after Infection with Influenza Viruses A/H5N1 and A/H1N1. Bull Exp Biol Med 166, 358–363 (2019). https://doi.org/10.1007/s10517-019-04350-1
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-019-04350-1