Summary
Sera of virgin and pregnant rats were examined for the presence of complement-fixing antibodies reacting with one or more of four preparations of homologous placentas. Many positive samples were encountered in both groups, the sole difference being a significantly higher incidence of anti-microsomal fraction antibodies in pregnant as compared to virgin animals. The results suggest that naturally occurring homologous anti-tissue antibodies are produced upon stimulation of the immune mechanism by cellular breakdown products as well as cross-reacting environmental antigens.
Zusammenfassung
Das Vorkommen von komplement-fixierenden Antikörpern, welche mit einem oder mehreren Präparaten von homologen Placentae reagieren, in den Blutseren von jungfräulichen und schwangeren Ratten wurde untersucht. Eine größere Anzahl positiver Fälle wurde in beiden Gruppen angetroffen; der einzige Unterschied zwischen beiden Gruppen war die bedeutend höhere Häufigkeit von Antikörpern gegen die mikrosomale Fraktion in den schwangeren Tieren im Vergleich zu den jungfräulichen. Die Resultate weisen darauf hin, daß die Produktion von natürlich vorkommenden homologen Anti-Gewebs-Antikörpern nicht nur durch die Stimulation des Immun-Mechanismus durch Zellzerfallsprodukte, sondern auch durch kreuzreagierende Umgebungsantigene geschieht.
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This investigation was supported by grant No. BSS-CD-IS-7 from the Public Health Service, Bureau of State Service, U.S.A.
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Boss, J.H., Nelken, D. Antibodies to species homologous tissue antigens in the rat. Z. med. Mikrobiol. u. Immunol. 154, 204–209 (1968). https://doi.org/10.1007/BF02123133
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DOI: https://doi.org/10.1007/BF02123133