Abstract
We wanted to clarify whether the postprandial intestinal feedback control activated by nutrients in the distal gut exerts different effects on motility, transit of digesta, and absorption of nutrients in the proximal gut. Additionally, interrelationships among motility, transit, and absorption were to be elucidated because these relationships have only been investigated in the fasted state. In five minipigs, a 150-cm segment of the proximal jejunum was isolated by two cannulas. Motility of the jejunal segment was recorded by multiple strain gauges and analyzed by computerized methods. Markers (Cr- and Cu-EDTA) were used for the measurement of the flow rate, transit time, and absorption of nutrients. After a meal, the test segment was perfused with 2 kcal/min of an elemental diet over a period of 90 min. A feedback inhibition was activated by infusion of nutrients into the midgut at rates of 1–4 kcal/min. Saline was infused as control. With increasing energy loads infused into the midgut, the motility index and the length of contraction waves decreased, whereas the incidence of stationary contractions increased, ie, the motility changed from a propulsive to a segmenting pattern. These modulations of motility were associated with a linear decrease in the flow rate and a linear increase in transit time. Flow and transit were linearly correlated with each other. Additionally, the reduction in flow rate and the delay in luminal transit were associated with a linear increase in the absorption of nutrients. However, the increase in absorption induced by the feedback mechanism was small (7.3–13.4%) compared to the marked inhibition of the motility parameters (54–64%), the flow rate (59%), and the delay of transit (5.8-fold). Feedback control primarily modulated motor patterns and luminal flow, whereas the small increase in absorption was only a side effect due to the longer contact time of the nutrients with the mucosa.
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References
Hunt JN, Knox MT: Regulation of gastric emptying,In Handbook of Physiology, Section 6 Alimentary canal, Vol IV, Motility. W Heidel (ed). Baltimore, Waverly Press, 1968, pp 1917–1935
Cooke AR: Control of gastric emptying and motility. Gastroenterology 68:804–816, 1975
Spiller RC, Bloom SR, Silk DBA: The ileal brake—a compensatory slowing of jejunal transit following ileal fat infusion in man. Clin Sci 64:53P, 1983
Spiller RC, Trotman IF, Higgins BE, Ghatei MA, Grimble GK, Lee YC, Bloom SR: The ileal brake-inhibition of jejunal motility after ileal fat perfusion in man. Gut 25:365–374, 1984
Read NW, McFarlane A, Kinsman RI, Bates TE, Blackhall NW, Farrar BJ, Hall JC, Moss G, Morris AP, O'Neill B, Welch I, Lee Y, Bloom SR: Effect of infusion of nutrient solutions into the ileum on gastrointestinal transit and plasma levels of neurotensin and enteroglucagon. Gastroenterology 86:274–280, 1984
Spiller RC, Trotman IF, Adrian TE, Bloom SR, Misiewicz JJ, Silk DBA: Further characterisation of the ileal brake reflex in man—effect of ileal infusion of partial digests of fat, protein, and starch on jejunal motility and release of neurotensin, enteroglucagon and peptide YY. Gut 29:1042–1051, 1988
Welch IM, Cunningham KM, Read NW: Regulation of gastric emptying by ileal nutrients in humans. Gastroenterology 94:401–404, 1988
Siegle ML, Schmid HR, Ehrlein HJ: Effects of ileal infusions of nutrients on motor patterns of canine small intestine. Am J Physiol (Gastrointest Liver Physiol) 259:G78-G85, 1990
Fone DR, Horowitz M, Read NW, Dent J, Maddox A: The effect of terminal ileal triglyceride infusion on gastroduodenal motility and the intragastric distribution of a solid meal. Gastroenterology 98:568–575, 1990
Holgate AM, Read NW: Effect of ileal infusion of intralipid on gastrointestinal transit, ileal flow rate, and carbohydrate absorption in humans after ingestion of a liquid meal. Gastroenterology 88:1005–1011, 1985
Schemann M, Siegle ML, Sahyoun H, Ehrlein HJ: Computer analysis of intestinal motility: Effects of cholecystokinin and neurotensin on jejunal contraction patterns. Z Gastroenterol 24:262–268, 1986
Schemann M, Ehrlein HJ, Sahyoun H: Computerized method for pattern recognition of intestinal motility: Functional significance of the spread of contractions. Med Biol Eng Comput 23:143–149, 1985
Welch IM, Davison PA, Worlding J, Read NW: Effect of ileal infusion of lipid on jejunal motor patterns after a nutrient and nonnutrient meal. Am J Physiol (Gastrointest Liver Physiol) 255:G800-G806, 1988
Binnerts WT, van't Klooster AT, Frens AM: Soluble chromium indicator measured by atomic absorption in digestion experiments. Vet Rec 82:470, 1968
Wulschke S, Ehrlein HJ, Tsiamitas C: The control mechanisms of gastric emptying are not overridden by motor stimulants. Am J Physiol 251:G744-G751, 1986
Ehrlein HJ, Hiesinger E: Computer analysis of mechanical activity of gastroduodenal junction in unanaesthetized dogs. Q J Exp Physiol 67:17–29, 1982
Schemann M, Ehrlein HJ: Postprandial motor patterns of canine jejunal motility and transit of luminal contents. Gastroenterology 90:991–1000, 1986
Siegle ML, Ehrlein HJ: Digestive motor patterns and transit of luminal contents in canine ileum. Am J Physiol 254:G552-G559, 1988
Schmid HR, Ehrlein HJ, Feinle C: Effects of enteral infusion of nutrients on canine intestinal motor-patterns. J Gastrointest Motil 4:279–292, 1992
Rayner V, Wenham G: Small intestinal motility and transit by electromyography and radiology in the fasted and fed pig. J Physiol 379:245–256, 1986
Ruckebusch Y, Bueno L: The effect of feeding on the motility of the stomach and small intestine in the pig. Br J Nutr 35:397–405, 1976
Laplace JP: Organisation de la motricité de l'intestin gréle chez le porc et influence de l'alimentation. Ann Zootech 27:377–408, 1978
Modigliani R, Bernier JJ: Absorption of glucose, sodium and water by the human jejunum studied by intestinal perfusion with a proximal occluding balloon and at variable flow rates. Gut 12:184–193, 1971
Grimble GG, West MFE, Acuti AB, Rees RG, Hunjan MK, Webster JD, Frost PG, Path MRC, Silk DBA: Assessment of an automated chemiluminescence nitrogen analyzer for routine use in clinical nutrition. JPEN 12:100–106, 1988
Soper NJ, Chapman NJ, Kelly KA, Brown ML, Phillips SF, Go VLW: The “ileal brake” after ileal pouch-anal anastomosis. Gastroenterology 98:111–116, 1990
Brown NJ, Read NW, Richardson A, Rumsey RDE, Bogentoft C: Characteristics of lipid substances activating the ileal brake in the rat. Gut 31:1126–1129, 1990
Brown NJ, Rumsey RDE, Read NW: Effects of nutrient infusions into rat small intestinal isolated loops on gastrointestinal transit time. Neurogastroenterol Motil 6:49–54, 1994
Read NW, Aljanabi MN, Edwards CA, Barber DC: Relationship between postprandial motor activity in the human small intestine and the gastrointestinal transit of food. Gastroenterology 86:721–727, 1984
Kerlin P, Zinsmeister A, Phillips S: Relationship of motility to flow of contents in the human small intestine. Gastroenterology 82:701–706, 1982
Sarr MG, Kelly KA: Patterns of movement of liquids and solids through canine jejunum. Am J Physiol (Gastrointest Liver Physiol) 239:G497-G503, 1980
Bueno L, Fioramonti J, Ruckebusch Y: Rate of low of digesta and electrical activity of the small intestine in dogs and sheep. J Physiol 249:69–85, 1975
Siegle ML, Ehrlein HJ: Effects of various agents on ileal postprandial motor patterns and transit of chyme in dogs. Am J Physiol 257:G698-G703, 1989
Cowles VE, Sarna SK: Relation between small intestinal motor activity and transit in secretory diarrhea. Am J Physiol (Gastrointest Liver Physiol) 259:G420-G429, 1990
Johnson CP, Sarna SK, Cowles VE, Osborn JL, Zhu Y-R, Bonham L, Buchmann E, Baytiyeh R, Telford GL, Roza AM, Adams MB: Motor activity and transit in the autonomically denervated jejunum. Am J Surg 167:80–89, 1994
Fioramonti J, Bueno L, Ruckebusch M: Blood sugar oscillations and duodenal migrating myoelectric complexes. Am J Physiol 242:G15-G20, 1982
Rayner DV: The relationships between glucose absorption and insulin secretion and the migrating myoelectric complex in the pig. Exp Physiol 76:67–76, 1991
Bueno L, Fioramonti J: Patterns of intestinal motility and their relationship with transit of digesta and absorption.In The Relationships between Intestinal Motility and Epithelial Transport. NW Read (ed). Janssen Research Council, 1986, pp 85–96
Sarr MG, Kelly KA, Phillips SF: Canine jejunal absorption and transit during interdigestive and digestive motor states. Am J Physiol (Gastrointest Liver Physiol) 239:G167-G173, 1980
Fioramonti J, Ruckebusch M: Motricité et absorption du glucose au niveau de l'intestin gréle chez le mouton. C R Soc Biol 171:964–969, 1977
Johansson C: Studies of gastrointestinal interactions. VII. Characteristics of the absorption patterns of sugar, fat and protein for composite meals in man. A quantitative study. Scand J Gastroenterol 10:33–42, 1975
Holgate AM, Read NW: Relationship between small bowel transit time and absorption of a solid meal. Dig Dis Sci 28:812–819, 1983
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The study was supported by the Deutsche Forschungsgemeinschaft, grant Eh 64/6-3.
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Huge, A., Weber, E. & Ehrlein, HJ. Effects of enteral feedback inhibition on motility, luminal flow, and absorption of nutrients in proximal gut of minipigs. Digest Dis Sci 40, 1024–1034 (1995). https://doi.org/10.1007/BF02064192
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DOI: https://doi.org/10.1007/BF02064192