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Solvent extraction and radiometric determination of3H-stobadine in biological material

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Abstract

A simple and rapid radiochemical method for the efficient and selective isolation of3H-stobadine from plasma, urine and organ homogenates has been developed. The method comprises the extraction of3H-stobadine from the biological matrix containing 2M Na2CO3 into n-hexane followed by scrubbing of partly coextracted metabolites into an equal volume of 2M Na2CO3. The specificity of the procedure presented is demonstrated by TLC and the comparison of distribution coefficients of authentic and apparent (isolated) substances.

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References

  1. A. šTOLC, V. BAUER, L. BENEŠ, M. TICHÝ, Czech. patent 229067, 1983.

  2. V. ŠČASNÁR, L. BENEŠ, Š., BEZEK, T. TRNOVEC, Radiochem. Radioanal. Letters, 59 (1983) 45.

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  4. M. ŠTEFEK, L. BENEŠ, M. JERGELOVÁ, V. ŠČASNÁR L. TURI-NAGY, P. KOČIŠ, Xenobiotica (submitted for publication).

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Authors and Affiliations

  1. Institute of Experimental Pharmacology, Centre of Physiological Sciences, Slovak Academy of Sciences, Dúbravská cesta 9, 842 16, Bratislava, Czechoslovakia

    V. Ščasnár & M. Štefek

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  1. V. Ščasnár
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  2. M. Štefek
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Ščasnár, V., Štefek, M. Solvent extraction and radiometric determination of3H-stobadine in biological material. Journal of Radioanalytical and Nuclear Chemistry, Articles 111, 117–122 (1987). https://doi.org/10.1007/BF02060527

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  • DOI: https://doi.org/10.1007/BF02060527

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