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Trichinella spiralis: Acceleration and inhibition of cyst calcification in rats

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Summary

Daily administration of vitamin D3 (75,000 IU/kg b.wt) for 7 days acceleratedTrichinella spiralis cyst calcification in rats with a 14-week-old infection. When disodium ethane-1-hydroxy-1,1-diphosphonate (EHDP) was administered (50 mg/kg b.wt) from 2 days before until 2 days after vitamin D3 treatment, cyst calcification was inhibited. Thus, the ability to inhibitT. spiralis calcification has been demonstrated for the first time.

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References

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Author notes

  1. A. L. Newsome

    Present address: Dept of Biology, Memphis State University, 38152, Memphis, Tenn, USA

Authors and Affiliations

  1. Department of Biological Sciences, Eastern Kentucky University, 40475, Richmond, Kentucky, USA

    A. L. Newsome & J. P. Harley

Authors
  1. A. L. Newsome
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  2. J. P. Harley
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Additional information

Supported in part by EKU faculty research grant No. 03-05.

Much appreciation goes to Dr Gordon S. Hassings and the Proctor and Gamble Company, Miami Valley Laboratories, Cincinnati, Ohio USA for providing the EHDP used in this study.

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Newsome, A.L., Harley, J.P. Trichinella spiralis: Acceleration and inhibition of cyst calcification in rats. Experientia 34, 1567–1568 (1978). https://doi.org/10.1007/BF02034677

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  • DOI: https://doi.org/10.1007/BF02034677

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