Abstract
The case of a 52-year-old man with an ataxicspastic syndrome associated with dystonia, faciobuccolingual dyskinesias and partial epileptic seizures is reported. Neurological imaging showed aspecific brain stem parenchymal alterations. Cerebellar biopsy revealed calcifications and the accumulation of perivascular acid mucopolysaccharides compatible with a diagnosis of “Calcinosis Nucleorum Cerebri”, with the absence of any Ca/P metabolism disturbances or other diseases predisposing to calcium deposits showing it to be sporadic and idiopathic. We feel that this case description is interesting because of some of its particular aspects and that it may help in providing a better nosographic classification of these diseases.
Sommario
Descriviamo il caso di un uomo di 52 anni, affetto da una sindrome atasso-spastica associata a distonia, discinesie facio-buccolinguali, crisi epilettiche parziali. Le neuroimmagini mostrano alterazioni parenchimali troncoencefaliche e cerebellari di natura aspecifica. La biopsia cerebellare rileva calcificazioni ed accumulo di mucopolisaccaridi acidi perivascolari, compatibili con una diagnosi di “Calcinosis Nucleorum Cerebri”, sporadica ed idiopatica per l'assenza di disturbi del metabolismo Ca/P e di altre patologie predisponenti i depositi calcifici. Riteniamo interessante la descrizione del caso per alcuni suoi aspetti peculiari e per un miglior inquadramento nosografico di queste forme morbose.
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References
Adachi M., Wellmann K.F. andVolk B.W.:Histochemical studies on pathogenesis of idiopathic non-arteriosclerotic cerebral calcification. J. Neuropathol. Exp. Neurol., 27: 483–499, 1969.
Babbit D.P., Tang T., Dobbs J. andBerk R.:Idiopathic familial cerebrovascular ferrocalcinosis (Fahr's disease) and review of different diagnosis of intracranial calcification in children. Am. J. Roentgen 105: 352–358, 1969.
Bignami A. andPalladini G.:The nature of the calcified structures in the brain in hypoparathyroidism. Acta Neuropathol. 4: 527–537, 1965.
Cohen G.:The pathobiology of Parkinson's disease: biochemical aspect of dopamine neuron senescence. J. Neural. Transm. 19: 89–103, 1983.
Delacour A.:Ossification des capillaires du cerveau. Ann. Med. Psychol., 2me série, 2458–2461, 1850.
Di Bella P., Logullo F., Dionisi L. andAngeleri F.:Alcune considerazioni su un caso di Morbo di Fahr. Riv. di Neurol. 58: 175–179, 1988.
Ellie E., Julien J. andFerrer X.:Familial idiopathic striopallidodentate calcifications. Neurology, 39: 381–385, 1989.
Fahr R.: Idiopathische verkalkung der hirngefässe. Zentrabl. Allg. Path. Anat., 50: 129–133, 1931.
Halliwell B., Gutteridge J.M.C. andBlake D.:Oxygen free radicals and iron in relation to biology and medicine: some problems and concepts. Arch. Biochem. Biopsy. 246: 501–514, 1986.
Kazis A.D.:Contribution of CT scan to the diagnosis of Fahr's syndrome. Acta Neurol. Scand. 71: 206–211, 1985.
Kobayashi S., Yamadori I., Miki H. andOhmori M.:Idiopathic nonarteriosclerotic cerebral calcification (Fahr's disease): an electron microscopic study. Acta Neuropathol. (Ber). 73: 62–66, 1987.
Lowenthal A.:Striopallidodentate calcifications. In: “Handbook of Clinical Neurology”, Vinken P.J., Bruyn G.W., and Klawans H.L. eds., North Holland Publ Co., Amsterdam, Vol. 49, pp. 417–439, 1986.
Lowenthal A. andBruyn G.W.:Calcifications of the striopallidodentate system. In: “Handbook of Clinical Neurology”, Vinken P.J. and Bruyn G.W. eds., North Holland Publ. Co., Amsterdam, Vol. 6, pp. 703–726, 1968.
Morgante L., Vita G., Meduri M., Di Rosa A.E., Galatioto S., Coraci M.A. andDi Perri R.:Fahr's syndrome: local inflammatory factors in the pathogenesis of calcification. J. Neurol. 233: 19–22, 1986.
Palladini G., Alfei L. andAppicciutoli L.: Osservazioni istochimiche sui corpora arenacea dell'epifisi umana. Arch. Ital. Anat. Embriol. 70: 532–537, 1965.
Palladini G., Alfei L. andConforti A.:Fissazione della tetraciclina a strutture calcificate non ossee. II. Istochimica della calcificazione distrofica renale da sublimato e substrato di fissazione del fluorocromo. Riv. Istoch. Nor. Pat., 11: 161–180, 1965.
Palladini G., Appicciutoli L. andBignami A.: Studio istochimico di calcificazioni cerebrali. Accademia Nazionale dei Lincei, S. VIII, 37: 104–107, 1964.
Palladini G. andBignami A.: Studio istochimico delle calcificazioni cerebrali nell'ipoparatiroidismo. Accademia Nazionale dei Lincei, Serie VIII, 36: 566–571, 1964.
Schiffer D.:Calcifications in nervous tissue. In Minckler J. (Ed.), Pathology of the Nervous System. McGraw-Hill N.Y., Vol. 2, pp. 1342–1360, 1971.
Smeyers-Verbeke J., Michotte Y., Pelsmaeckers J., Lowenthal A., Massart D.L., Dekegel D. andKarcher D.:The chemical composition of idiopathic nonarteriosclerotic cerebral calcifications. Nerology, 25: 48–57, 1975.
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Francia, A., Calandriello, L., Restante, R. et al. Striopallidodentate calcifications: nosographic, neuropathological and clinical proposal. Case report. Ital J Neuro Sci 17, 169–173 (1996). https://doi.org/10.1007/BF02000851
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DOI: https://doi.org/10.1007/BF02000851