Abstract
Chloroquine liberated a relatively low amount of histamine from isolated rat mast cells. In a dose-dependent way, this drug inhibited histamine liberation from mast cells stimulated with compound 48/80, A23187, concanavalin A plus phosphatidylserine (Con A+PS) and abolished histamine liberation induced by exaprolol. The degranulation was decreased in cells stimulated with 48/80, Con A+PS and exaprolol. Chloroquine significantly inhibited the formation of thromboxane B2 in mast cells stimulated with 48/80, Con A+PS and A23187. We assume that chloroquine interferes with mast cells at a plasmic membrane site as well as intracellularly.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
R. Nosál, Ö. Ericsson, F. Sjöqvist and M. Durisová,Distribution of chloroquine in human blood fractions. Meth. Find. Exptl. Clin. Pharmacol.10, 581–587 (1988).
K. M. Lloyd,Figurative erythema due to antimalarial therapy. Cutis (N.Y.)4, 67–69 (1968).
L. T. Webster,Drugs used in chemotherapy of protozoal infection. InThe pharmacological basis of therapeutics. (Eds. A. G. Gilman, L. S. Goodman, T. W. Rall and F. Murad), pp. 1029–1048. McMillan, New York 1985.
A. Wada, S. Sakurai, H. Kobayashi, N. Yanagihara and F. Izumi,Suppression by phospholipase A 2 inhibitors of secretion of catecholamines from isolated adrenal medullary cells by suppression of cellular calcium uptake. Biochem. Pharmacol.32, 1175–1178 (1983).
R. Nosál, J. Pecivová and K. Drábiková,Evidence for intracellular histamine liberation in isolated rat mast cells. Agents and Actions12, 601–607 (1982).
K. Drábiková, J. Pecivová, M. Petríková, V. Jancinová and R. Nosál,The effect of betaadrenoceptor blocking drugs on histamine liberation, prostaglandin synthesis and phospholipid turnover in isolated mast cells stimulated with concanavalin A. Agents and Actions30, 77–80 (1990).
L. L. Gustafsson, O. Walker, G. Alván, B. Beerman, F. Estevez, L. Gleisner, B. Lindström and F. Sjöqvist,Disposition of chloroquine in man after single intravenous and oral doses. Br. J. Clin. Pharmacol.15, 471–479 (1983).
J. L. Costa, D. D. Fay and K. L. Kirk,Quinacrine and other basic amines in human platelets. Subcellular compartmentation and effects on serotonin. Res. Commun. Chem. Pathol. Pharmacol.43, 25–42 (1984).
R. S. Siraganian,Mast cells and basophils. InInflammation: Basic principles and clinical correlates. (Eds. J. I. Gallin, I. M. Goldstein and R. Snyderman) pp. 513–542. Raven Press, New York 1988.
N. P. Hurst, J. K. French, A. L. Bell, G. Nuki, M. L. O'Donnell, W. H. Betts and L. G. Cleland,Differential effects of mepacrine, chloroquine and hydroxychloroquine on superoxide anion generation, phospholipid methylation and arachidonic acid release by human blood monocytes. Biochem Pharmacol.35, 3083–3089 (1986).
F. Antoni, A. Hrabák and I. Csuka,Effect of emetine and chloroquine on phagocytic process of rat macrophages. Biochem. Pharmacol.35, 2869–2874 (1986).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Nosál, R., Drábiková, K. & Pecivová, J. Effect of chloroquine on isolated mast cells. Agents and Actions 33, 37–40 (1991). https://doi.org/10.1007/BF01993121
Issue Date:
DOI: https://doi.org/10.1007/BF01993121