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Captopril-induced enhancement of fMet-Leu-Phe-activated enzyme secretion from neutrophils

  • General Inflammation
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Abstract

Captopril enhanced exocytotic enzyme secretion from rabbit peritoneal neutrophils activated by suboptimal concentrations of fMet-Leu-Phe. For optimal enhancement the presence of Ca2+ was required. Captopril did not induce enzyme secretion by its own, and there was little effect on PMA-induced exocytosis. Cyclic GMP level of neutrophils was transiently enhanced by captopril. Methylene blue inhibited both captopril-induced enhancement of enzyme release and of cGMP levels. From our studies and from reports in the literature it appears that cGMP level-enhancing compounds may have both activating or inhibitory properties.

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  1. Department of Medical Biochemistry, University of Leiden, POB 9503, 2300 RA, Leiden, The Netherlands

    J. G. R. Elferink

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  1. J. G. R. Elferink
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Elferink, J.G.R. Captopril-induced enhancement of fMet-Leu-Phe-activated enzyme secretion from neutrophils. Agents and Actions 38 (Suppl 2), C136–C138 (1993). https://doi.org/10.1007/BF01991163

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