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Platelet activating factor (PAF) and lyso-PAF in inflamed human skin

  • Proceedings of the Joint World Congress of the International Association of Inflammation Societies and the European Inflammation Society, Austria Center, Vienna, October 10–15, 1993
  • Skin Inflammation and Disease
  • Published:
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Abstract

The extent of PAF synthesis and its role in inflammatory skin disorders are not known. Skin exudates were collected from suction blisters or bbrasions on healthy and inflamed human skin and analysed by gc-ms. The mean PAF andlyso-PAF values for skin of healthy subjects were 1.86±0.92 (n=7) and 160±21 (n=8) nM, respectively, in suction blister exudates, and 0.38±0.08 (n=14) and 11.0±1.9 (n=13) pmol/abrasion, respectively. PAF levels were not altered in psoriasis, nickel contact dermatitis, delayed pressure urticaria, mastocytosis or immediate and late phase reactions to antigen. Significantly, lesslyso-PAF was found in uninvolved skin of psoriasis. Increasedlyso-PAF was found in nickel contact dermatitis compared with untreated skin of the same subjects or skin or normal healthy volunteers. We conclude that, if PAF is a significant mediator of inflammation in human skin, it may remain associated with the synthesising cell or act in its immediate proximity.

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Authors and Affiliations

  1. St. John's Institute of Dermatology, UMDS, St. Thomas' Hospital, SE1 7EH, London, UK

    R. M. Barr, M. Judge, A. I. Mallet, A. Kobza-Black, R. Barlow & M. W. Greaves

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  1. R. M. Barr
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  2. M. Judge
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  3. A. I. Mallet
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  4. A. Kobza-Black
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  5. R. Barlow
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  6. M. W. Greaves
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Barr, R.M., Judge, M., Mallet, A.I. et al. Platelet activating factor (PAF) and lyso-PAF in inflamed human skin. Agents and Actions 41 (Suppl 2), C260–C261 (1994). https://doi.org/10.1007/BF01987662

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  • DOI: https://doi.org/10.1007/BF01987662

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