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Platelets and Skin Disorders

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Platelets in Thrombotic and Non-Thrombotic Disorders

Abstract

Recent accumulating evidence indicates that platelets act as effector cells in initiating and modulating inflammatory and immune responses in various organs including the skin. On activation in response to various factors such as chemokines and microbial toxins, platelets express adhesive and immune receptors such as P-selectin and Toll-like receptors on their surface and release soluble mediators such as chemokines, cytokines, and antimicrobial peptides. In patients with inflammatory skin disorders such as atopic dermatitis and psoriasis, platelets circulate in an activated state, and the degree of platelet activation correlates with disease severity. Platelets are deeply involved in the pathogenesis of several inflammatory skin disorders such as atopic dermatitis, contact dermatitis, psoriasis, urticaria, and infectious diseases via formation of platelet-leukocyte complexes, releasing chemotactic factors, inhibiting monocytic apoptosis, inducing neutrophil phagocytosis, promoting allergic sensitization, and releasing antimicrobial peptides.

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References

  • Ahlehoff O, Gislason GH, Lindhardsen J et al (2011) Psoriasis carries an increased risk of venous thromboembolism: a Danish Nationwide Cohort Study. PLoS One 6, e18125

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Asero R, Tedeschi A, Coppola R et al (2007) Activation of the tissue factor pathway of blood coagulation in patients with chronic urticaria. J Allergy Clin Immunol 119:705–710

    Article  CAS  PubMed  Google Scholar 

  • Aslam R, Speck ER, Kim M et al (2006) Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-α production in vivo. Blood 107:637–641

    Article  CAS  PubMed  Google Scholar 

  • Beaulieu LM, Lin E, Morin KM et al (2011) Regulatory effects of TLR2 on megakaryocytic cell function. Blood 117:5963–5974

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Blair P, Rex S, Vitseva O et al (2009) Stimulation of Toll-like receptor 2 in human platelets induces a thromboinflammatory response through activation of phosphoinositide 3-kinase. Circ Res 104:346–354

    Article  CAS  PubMed  Google Scholar 

  • Boehncke WH, Boehncke S, Tobin AM et al (2011) The ‘psoriatic march’: a concept of how severe psoriasis may drive cardiovascular comorbidity. Exp Dermatol 20:303–307

    Article  PubMed  Google Scholar 

  • Bruijnzeel PL, Kujiper PH, Rihs S et al (1993) Eosinophil migration in atopic dermatitis. I: increased migratory responses to N-formyl-methionyl-leucyl-phenylalanine, neutrophil-activating factor, platelet-activating factor, and platelet factor 4. J Invest Dermatol 100:137–142

    Article  CAS  PubMed  Google Scholar 

  • Canpolat F, Akpinar H, Eskioǧlu F (2010) Mean platelet volume in psoriasis and psoriatic arthritis. Clin Rheumatol 29:325–328

    Article  PubMed  Google Scholar 

  • Chandrashekar L, Rajappa M, Revathy G et al (2015) Is enhanced platelet activation the missing link leading to increased cardiovascular risk in psoriasis? Clin Chim Acta 446:181–185

    Article  CAS  PubMed  Google Scholar 

  • Clark SR, Ma AC, Tavener SA et al (2007) Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood. Nat Med 13:463–469

    Article  CAS  PubMed  Google Scholar 

  • Corsini E, Galli CL (1988) Cytokines and irritant contact dermatitis. Toxicol Lett 102–3:277–282

    Google Scholar 

  • Daito J, Harada Y, Dai P et al (2014) Neutrophil phagocytosis of platelets in the early phase of 2,4,6-trinitro-1-chlorobenzene (TNCB)-induced dermatitis in mice. Acta Histochem Cytochem 47:67–74

    Article  PubMed  PubMed Central  Google Scholar 

  • Fujisawa T, Fujisawa R, Kato Y et al (2002) Presence of high contents of thymus and activation-regulated chemokine in platelets and elevated plasma levels thymus and activation-regulated chemokine and macrophage-derived chemokine in patients with atopic dermatitis. J Allergy Clin Immunol 110:139–146

    Article  CAS  PubMed  Google Scholar 

  • Gear ARL, Camerini D (2003) Platelet chemokines and chemokine receptors: linking hemostasis, inflammation, and host defense. Microcirculation 10:335–350

    Article  CAS  PubMed  Google Scholar 

  • Gelfand JM, Neimann AL, Shin DB et al (2006) Risk of myocardial infarction in patients with psoriasis. JAMA 296:1735–1741

    Article  CAS  PubMed  Google Scholar 

  • Gelfand JM, Dommasch ED, Shin DB et al (2009) The risk of stroke in patients with psoriasis. J Invest Dermatol 129:2411–2418

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hara T, Shimizu K, Ogawa F et al (2010) Platelets control leukocyte recruitment in a murine model of cutaneous arthus reaction. Am J Pathol 176:259–269

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hasegawa S, Pawankar R, Suzuki K et al (1999) Functional expression of the high affinity receptor for IgE (FcRI) in human platelets and its’ intracellular expression in human megakaryocytes. Blood 93:2543–2551

    CAS  PubMed  Google Scholar 

  • Hayashi S, Shimizu I, Miyauchi H et al (1985) Increased platelet aggregation in psoriasis. Acta Derm Venereol 65:258–262

    CAS  PubMed  Google Scholar 

  • Hayashi N, Chihara J, Kobayashi Y et al (1994) Effect of platelet-activating factor and platelet factor 4 on eosinophil adhesion. Int Arch Allergy Immunol 104(Suppl 1):57–59

    Article  CAS  PubMed  Google Scholar 

  • Hilger R, Neuber AK, König W (1991) Convention of leukotriene A4 by neutrophils and platelets from patients with atopic dermatitis. Immunology 74:689–695

    CAS  PubMed  PubMed Central  Google Scholar 

  • Joseph M, Capron A, Ameisen JC et al (1986) The receptor for IgE on human platelets. Eur J Immunol 16:306–312

    Article  CAS  PubMed  Google Scholar 

  • Kasperska-Zajac A, Rogala B, Nowakowski M (2005) Assessment of platelet activity as expressed by plasma levels of platelet factor 4 and beta-thromboglobulin in patients with chronic idiopathic urticaria. Exp Dermatol 14:515–518

    Article  CAS  PubMed  Google Scholar 

  • Kasperska-Zajac A, Brzoza Z, Rogala B (2008) Platelet function in cutaneous diseases. Platelets 19:317–321

    Article  CAS  PubMed  Google Scholar 

  • Katoh N (2009) Platelets as versatile regulators of cutaneous inflammation. J Dermatol Sci 53:89–95

    Article  CAS  PubMed  Google Scholar 

  • Katoh N, Kraft S, Weaaendorf J et al (2000) The high-affinity IgE receptor (FcεRI) blocks apoptosis in normal human monocytes. J Clin Invest 105:183–190

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Katoh N, Soga F, Nara T et al (2006) Effects of serotonin on the differentiation of human monocytes into dendritic cells. Clin Exp Immunol 46:354–361

    Article  Google Scholar 

  • Kitagaki H, Fujisawa S, Watanabe K et al (1995) Immediate-type hypersensitivity response followed by a late reaction is induced by repeated epicutaneous application of contact sensitizing agents in mice. J Invest Dermatol 105:749–755

    Article  CAS  PubMed  Google Scholar 

  • Kitagaki H, Ono N, Hayakawa K et al (1997) Repeated elicitation of contact hypersensitivity induces a shift in cutaneous cytokine milieu from a T helper cell type 1 to a T helper cell type 2 profile. J Immunol 159:2484–2491

    CAS  PubMed  Google Scholar 

  • Kraemer BF, Campbell RA, Schwertz H et al (2011) Novel anti-bacterial activities of β-defencin 1 in human platelets: suppression of pathogen growth and signaling of neutrophil extracellular trap formation. PLoS Pathog 7, e1002355

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Krijgsveld J, Zaat SAJ, Meeldijk J et al (2000) Thrombocidins, microbicidal proteins from human blood platelets, are C-terminal deletion products of CXC chemokines. J Biol Chem 275:20374–20381

    Article  CAS  PubMed  Google Scholar 

  • Lang D, DOhle F, Terstesse M et al (2002) Downregulation of monocyte apoptosis by phagocytosis of platelets: involvement of a caspase-9, caspase-3, and heat shock protein 70-dependent pathway. J Immunol 168:6152–6158

    Article  CAS  PubMed  Google Scholar 

  • Lawlor F, Kobza BA, Breathnach AS et al (1989) A timed study of the histopathology, direct immunofluorescence and ultrastructural findings in idiopathic cold-contact urticaria over a 24-h period. Clin Exp Dermatol 14:416

    Article  CAS  PubMed  Google Scholar 

  • Leung DYM (2013) New insights into atopic dermatitis: role of skin barrier and immune dysregulation. Allergol Int 62:151–161

    Article  CAS  PubMed  Google Scholar 

  • Ludwig RJ, Schultz JE, Boehncke WH et al (2004) Activated, not resting, platelets increase leukocyte rolling in murine skin utilizing a distinct set of adhesion molecules. J Invest Dermatol 122:830–836

    Article  CAS  PubMed  Google Scholar 

  • Ludwig RJ, Bergmann P, Garbaraviciene J et al (2010) Platelet, not endothelial, P-selectin expression contributes to generation of immunity in cutaneous contact hypersensitivity. Am J Pathol 176:1339–1345

    Article  PubMed  PubMed Central  Google Scholar 

  • Lundblad RL, White GC II (2005) The interaction of thrombin with blood platelets. Platelets 16:373–385

    Article  CAS  PubMed  Google Scholar 

  • Magen E, Mishal J, Zeldin Y et al (2010) Increased mean platelet volume and C-reactive protein levels in patients with chronic urticaria with a positive autologous serum skin test. Am J Med Sci 339:504–508

    Article  PubMed  Google Scholar 

  • Martin JF, Trowbridge EA, Salmon G et al (1983) The biological significance of platelet volume: its relationship to bleeding time, thromboxane B2 production and megakaryocyte nuclear DNA concentration. Thromb Res 32:443–460

    Article  CAS  PubMed  Google Scholar 

  • Matsuda H, Ushio H, Geba GP et al (1997) Human platelets can initiate T cell-dependent contact sensitivity through local serotonin release mediated by IgE antibodies. J Immunol 158:2891–2897

    CAS  PubMed  Google Scholar 

  • Mehta NN, Azfar RS, Shin DB et al (2010) Patients with severe psoriasis are at increased risk of cardiovascular mortality: cohort study using the General Practice Research Database. Eur Heart J 31:1000–1006

    Article  PubMed  Google Scholar 

  • Moritz DR, Rodewald HR, Gheyselinck J et al (1998) The IL-1 receptor-related T1 antigen is expressed on immature and mature mast cells and on fetal blood mast cell progenitors. J Immunol 161:4866–4874

    CAS  PubMed  Google Scholar 

  • Morrell CN, Aggrey AA, Chapman LM et al (2014) Emerging roles for platelets as immune and inflammatory cells. Blood 123:2759–2767

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Nakamura N, Tamagawa-Mineoka R, Ueta M et al (2015) Toll-like receptor 3 increases allergic and irritant contact dermatitis. J Invest Dermatol 135:411–417

    Article  CAS  PubMed  Google Scholar 

  • Nastalek M, Potaczek DP, Wojas-Pelc A et al (2011) Plasma platelet activation markers in patients with atopic dermatitis and concomitant allergic diseases. J Dermatol Sci 64:79–82

    Article  CAS  PubMed  Google Scholar 

  • Neuber K, Hilger RA, König W (1992) Differential increase in 12-HETE release and CD29/CD49f expression of platelets from normal donors and from patients with atopic dermatitis. Int Arch Allergy Immunol 98:339–342

    Article  CAS  PubMed  Google Scholar 

  • O’ Neill LA, Dinarello CA (2000) The IL-1 receptor/Toll-like receptor superfamily: crucial receptors for inflammation and host defense. Immunol Today 21:206–209

    Article  Google Scholar 

  • Pushparaj PN, Tay HK, H'ng SC et al (2009) The cytokine interleukin-33 mediates anaphylactic shock. Proc Natl Acad Sci U S A 106:9773–9778

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rogala B, Gumprecht J, Glück J (1999) Platelet aggregation in atopic dermatitis. Platelets 10:341–344

    Article  CAS  PubMed  Google Scholar 

  • Savinko T, Matikainen S, Saarialho-Kere U et al (2012) IL-33 and ST2 in atopic dermatitis: expression profiles and modulation by triggering factors. J Invest Dermatol 132:1392–1400

    Article  CAS  PubMed  Google Scholar 

  • Scheuerer B, Ernst M, Dürrbaum-Landmann I et al (2000) The CXC-chemokine platelet factor 4 promotes monocyte survival and induces monocyte differentiation into macrophages. Blood 95:1158–1166

    CAS  PubMed  Google Scholar 

  • Schmitz J, Owyang A, Oldham E et al (2005) IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity 23:479–490

    Article  CAS  PubMed  Google Scholar 

  • Semple JW, Italiano JE Jr, Freedman J (2011) Platelets and the immune continuum. Nat Rev Immunol 11:264–274

    Article  CAS  PubMed  Google Scholar 

  • Senaldi G, Piguet PF (1997) Platelets play a role in the pathogenesis of the irritant reaction in mice. J Invest Dermatol 108:248–252

    Article  CAS  PubMed  Google Scholar 

  • Shiraki R, Inoue N, Kawasaki S et al (2004) Expression of Toll-like receptors on human platelets. Thromb Res 113:379–385

    Article  CAS  PubMed  Google Scholar 

  • Soga F, Katoh N, Inoue T et al (2007a) Serotonin activates human monocytes and prevents apoptosis. J Invest Dermatol 127:1947–1955

    Article  CAS  PubMed  Google Scholar 

  • Su VYF, Chen TJ, Yeh CM (2014) Atopic dermatitis and risk of ischemic stroke: a nationwide population-based study. Ann Med 46:84–89

    Article  PubMed  Google Scholar 

  • Swaim AF, Field DJ, Fox-Talbot K et al (2010) Platelets contribute to allograft rejection through glutamate receptor signaling. J Immunol 185:6999–7006

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tamagawa-Mineoka R (2015) Important roles of platelets as immune cells in the skin. J Dermatol Sci 77:93–101

    Article  CAS  PubMed  Google Scholar 

  • Tamagawa-Mineoka R, Katoh N (2016) Platelets. In: Kabashima K (ed) Immunology of the skin. Springer Japan, Tokyo

    Google Scholar 

  • Tamagawa-Mineoka R, Katoh N, Ueda E et al (2007) The role of platelets in leukocyte recruitment in chronic contact hypersensitivity induced by repeated elicitation. Am J Pathol 170:2019–2029

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tamagawa-Mineoka R, Katoh N, Kishimoto S (2008) Elevated platelet activation in patients with atopic dermatitis and psoriasis: increased plasma levels of β-thromboglobulin and platelet factor 4. Allergol Int 57:391–396

    Article  CAS  PubMed  Google Scholar 

  • Tamagawa-Mineoka R, Katoh N, Kishimoto S (2009a) Platelet-derived microparticles and soluble P-selectin as platelet activation markers in patients with atopic dermatitis. Clin Immunol 131:495–500

    Article  CAS  PubMed  Google Scholar 

  • Tamagawa-Mineoka R, Katoh N, Kishimoto S (2009b) Platelets play important roles in the late phase of the immediate hypersensitivity reaction. J Allergy Clin Immunol 123:581–587

    Article  CAS  PubMed  Google Scholar 

  • Tamagawa-Mineoka R, Katoh N, Kishimoto S (2010) Platelet activation in patients with psoriasis: increased plasma levels of platelet-derived microparticles and soluble P-selectin. J Am Acad Dermatol 62:621–626

    Article  CAS  PubMed  Google Scholar 

  • Tamagawa-Mineoka R, Okuzawa Y, Masuda K et al (2014) Increased serum levels of interleukin-33 in patients with atopic dermatitis. J Am Acad Dermatol 70:882–888

    Article  CAS  PubMed  Google Scholar 

  • Tang YQ, Yaeman MR, Selsted ME (2002) Antimicrobial peptides from human platelets. Infect Immun 70:6524–6533

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Thompson CB, Eaton KA, Princiotta SM et al (1982) Size dependent platelet subpopulations: relationship of platelet volume to ultrastructure, enzymatic activity and function. Br J Haematol 50:509–519

    Article  CAS  PubMed  Google Scholar 

  • Unno H, Morita H, Saito H et al (2014) Platelets constitutively express interleukin-33 protein. J Allergy Clin Immunol 133:AB401

    Article  Google Scholar 

  • Unno H, Morita H, Futamura K et al (2015) Platelets constitutively express interleukin-33 protein and modulate eosinophilic airway inflammation. J Allergy Clin Immunol 135:AB147

    Google Scholar 

  • von Hundelshausen P, Weber C (2007) Platelets as immune cells. Bridging inflammation and cardiovascular disease. Circ Res 100:27–40

    Article  Google Scholar 

  • Wang Y, Gao H, Loyd CM et al (2012) Chronic skin-specific inflammation promotes vascular inflammation and thrombosis. J Invest Dermatol 132:2067–2075

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wasserman SI, Ginsberg MH (1984) Release of platelet factor 4 into the blood after cold challenge of patients with cold urticaria. J Allergy Clin Immunol 74:275–279

    Article  CAS  PubMed  Google Scholar 

  • Watanabe O, Natori K, Tamari M et al (1999) Significantly elevated expression of PF4 (platelet factor 4) and eotaxin in the NOA mouse, a model for atopic dermatitis. J Hum Genet 44:173–176

    Article  CAS  PubMed  Google Scholar 

  • Xu D, Chan WL, Leung BP et al (1998) Selective expression of a stable cell surface molecule on type 2 but not type 1 helper T cells. J Exp Med 187:787–794

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Xu H, Zhang X, Mannon RB et al (2006) Platelet-derived or soluble CD154 induces vascularized allograft rejection independent of cell-bound CD154. J Clin Invest 116:769–774

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Acknowledgments

The author thanks Professor Norito Katoh for reviewing this article.

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Authors and Affiliations

  1. Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan

    Risa Tamagawa-Mineoka

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  1. Risa Tamagawa-Mineoka
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Correspondence to Risa Tamagawa-Mineoka .

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Editors and Affiliations

  1. Department of Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia , Perugia, Italy

    Paolo Gresele

  2. Houston Methodist Hospital , Houston, Texas, USA

    Neal S. Kleiman

  3. Bloodworks Northwest, University of Washington , Seattle, Washington, USA

    José A. Lopez

  4. Sackler Inst of Pulmonary Pharmacol, King’s College London, London, United Kingdom

    Clive P. Page

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Tamagawa-Mineoka, R. (2017). Platelets and Skin Disorders. In: Gresele, P., Kleiman, N., Lopez, J., Page, C. (eds) Platelets in Thrombotic and Non-Thrombotic Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-47462-5_76

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