Abstract
In rats, severe and almost always fatal picrotoxin poisoning can be prevented by various steroids such as ethylestrenol, SC-11927, spironolactone, norbolethone, oxandrolone, prednisolone and progesterone. On the other hand, triamcinolone, desoxycorticosterone, hydroxydione, cholesterol and β-sitosterol do not prevent picrotoxin convulsions.
There appears to be a close relationship between the ability of various steroids to protect against picrotoxin convulsions and their catatoxic actions previously observed in other test systems.
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Selye, H. Resistance to picrotoxin poisoning induced by catatoxic steroids. Agents and Actions 1, 133–135 (1970). https://doi.org/10.1007/BF01982399
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DOI: https://doi.org/10.1007/BF01982399