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, Volume 1, Issue 3, pp 133–135 | Cite as

Resistance to picrotoxin poisoning induced by catatoxic steroids

  • Hans Selye
Research Reports


In rats, severe and almost always fatal picrotoxin poisoning can be prevented by various steroids such as ethylestrenol, SC-11927, spironolactone, norbolethone, oxandrolone, prednisolone and progesterone. On the other hand, triamcinolone, desoxycorticosterone, hydroxydione, cholesterol and β-sitosterol do not prevent picrotoxin convulsions.

There appears to be a close relationship between the ability of various steroids to protect against picrotoxin convulsions and their catatoxic actions previously observed in other test systems.


Cholesterol Steroid Progesterone Prednisolone Spironolactone 
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Copyright information

© Birkhäuser Verlag 1970

Authors and Affiliations

  • Hans Selye
    • 1
  1. 1.Institut de Médecine et de Chirurgie expérimentalesUniversité de MontréalMontréalCanada

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