Abstract
Picrotoxin is extracted from the seeds of Radix Cocculi Trilobi. The pharmacological effects of picrotoxin are focused on the central nervous system and GABA receptor. Picrotoxin also showed direct effects on the heart, including inhibiting cardiac-specific conduction system and decreasing heart rate and cardiac contractility, as well as cardiac action potential. As a GABA receptor antagonist, picrotoxin is extensively studied for its strong effects on the mesencephalon and oblongata. Its application in serious barbital poisoning patients achieves satisfactory results. However, picrotoxin overdose may cause cramp, respiratory center inhibition, and vomiting. Thus, the clinical symptoms of the patients should be watched closely, and their respiration, pulse, and blood pressure should be monitored when using picrotoxin.
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References
Dichoso WC. Research information series on ecosystems–volume 12 no.2. Useful plant species with toxic substance. DENR, 2000.
Verpoorte R, Siwon J, Tieken MEM, Baerheim SA. Studies on Indonesian medicinal plants. V. The alkaloids of Anamirta cocculus. J Nat Prod. 1981;44(2):221–4.
Allen AH. Bitters of cocculus indicus. Commercial organic analysis -Vol. III part III. 2nd ed. Philadelphia: P. Blakiston, Son &Co; 1896.
Duke JA. Ethnobotanical uses. Germplasm resources information network: Dr. Duke’s phytochemical and ethnobotanical databases. USDA, 1995.
Porter N. Webster’s revised unabridged dictionary. Springfield: G. & C. Merriam Co; 1913.
Newland CF, Cull-Candy SG. On the mechanism of action of picrotoxin on GABA receptor channels in dissociated sympathetic neurones of the rat. J Physiol. 1992;447(1):191–213.
Rho JM, Donevan SD, Rogawski MA. Direct activation of GABA-A receptors by barbiturates in cultured rat hippocampal neurons. J Physiol. 1996;497(2):509–22.
Han D, Zhang G, Li X. Effect of picrotoxin on nociceptive discharges of parafascicular neurons of thalamus. J Hubei Med Coll. 1990;11(1):21–3.
Zhang Z. Effect of intracerebroventricular injection of picrotoxin on electroacupuncture in rats. J Wuhan Med Coll. 1985;4:292–3.
Xu C, He J, Meng X, et al. Blocking effect of picrotoxin on decreased blood pressure induced by hypoxia in rabbits. Chin J Appl Physiol. 1998;14(2):123–4.
Yuan X, Xu J, Shi H, et al. Effect of picrotoxin on rate, contractility, and action potential of isolated frog heart. J Third Mil Med Univ. 1986;8(Suppl):37–41.
Mao Y, Wang Y. Cases report of three barbital poisoning patients rescued using picrotoxin. Jiangxi Med J. 1965;5(8):955.
Sierra-Paredes G, Galán-Valiente J, Vazquez-Illanes MD, et al. Extracellular amino acids in the rat hippocampus during picrotoxin threshold seizures in chronic microdialysis experiments. Neurosci Lett. 1998;248(1):53–6.
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© 2018 Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China
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Xu, HL., Du, LD., Du, GH. (2018). Picrotoxin. In: Natural Small Molecule Drugs from Plants. Springer, Singapore. https://doi.org/10.1007/978-981-10-8022-7_50
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DOI: https://doi.org/10.1007/978-981-10-8022-7_50
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