Summary
A small i.v. dose (3 mg/kg) of a light lanthanon, praseodymium, impairs the drug metabolizing capacity of both the smooth and rough fractions of rat liver endoplasmic reticulum. This decrease in the activity of drug metabolizing enzymes and in the amount of cytochromes P-450 and b5 is more pronounced in the rough endoplasmic reticulum fraction.
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References
P. Arvela, Progr. Pharmac.2, 71 (1979).
G. Magnusson, Acta pharmac. tox.20, suppl. 3 (1963).
S. Fleischer and M. Kervina, Meth. Enzymol.31, 6 (1974).
R. Kuntzman, L.C. Mark, L. Brand, M. Jacobsen, M. Levin and A.H. Conney, J. Pharmac. exp. Therap.152, 151 (1966).
R. Kato and J.R. Gillette, J. Pharmac. exp. Therap.150, 279 (1965).
T. Omura and R. Sato, J. biol. Chem.239, 2370 (1964).
O.H. Lowry, N.J. Rosebrough, A.L. Farr and R.J. Randall, J. biol. Chem.193, 265 (1951).
P. Arvela and N.T. Kärki, Acta pharmac. tox.31, 380 (1972).
B. v. Lehmann, E. Oberdisse, O. Grajewsky and H.-R. Arntz, Arch. Tox.34, 89 (1975).
M.J. Coon, H.W. Strobel, A.P. Autor, J. Heidema and W. Duppel, Biochem. J.125, 2P (1971).
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Arvela, P., v. Lehmann, B., Grajewski, O. et al. Effect of praseodymium on drug metabolism in rat liver smooth and rough endoplasmic reticulum. Experientia 36, 860–861 (1980). https://doi.org/10.1007/BF01978615
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DOI: https://doi.org/10.1007/BF01978615