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Effects of inhibition and stimulation of Na+−K+ active transport on the resting membrane input conductance of the guinea-pig ventricle

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Summary

The effects of inhibition by ouabain and stimulation by high frequency drive of the sarcolemmal Na+−K+ active transport system on the resting input conductance (gi) of guinea-pig ventricular muscles were determined. Although both pump inhibition and stimulation were associated with changes in electrophysiological properties of the muscles, neither had a significant effect on gi.

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Authors and Affiliations

  1. Department of Physiology and Pharmacology, Bowman Gray School of Medicine of Wake Forest University, 27103, Winston-Salem, NC, USA

    Thomas M. Nosek

  2. Department of Physiology, Medical College of Georgia, 30912, Augusta, GA, USA

    Thomas M. Nosek

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  1. Thomas M. Nosek
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Supported by a grant from the North Carolina Heart Association.

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Nosek, T.M. Effects of inhibition and stimulation of Na+−K+ active transport on the resting membrane input conductance of the guinea-pig ventricle. Experientia 36, 844–846 (1980). https://doi.org/10.1007/BF01978605

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