Skip to main content
SpringerLink
Log in

Effect of Purine Co-Transmitters on Automatic Activity Caused by Norepinephrine in Myocardial Sleeves of Pulmonary Veins

  • PHYSIOLOGY
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

We studied the effect of extracellular purine nucleotides (NAD+ and ATP) on spontaneous arrhythmogenic activity caused by norepinephrine in myocardial sleeves of pulmonary veins. In pulmonary veins, NAD+ and ATP reduced the frequency of action potentials and their duration at regular type of spontaneous activity caused by norepinephrine. NAD+ and ATP lengthened the intervals between spike bursts at periodic (burst) type of spontaneous activity. In addition, ATP shortened the duration of spike bursts and the number of action potentials in the “bursts” caused by norepinephrine in the pulmonary veins. It was hypothesized that NAD+ and ATP attenuate the effects of sympathetic stimulation and when released together with norepinephrine from sympathetic endings in vivo, probably, reduce arrhythmogenic activity in myocardial sleeves of pulmonary veins.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Kuzmin VS, Abramochkin DV, Sukhova GS, Rozenshtraukh LV. Influence of ADP-ribose, AMP and adenosinc on bioelectric activity of hibernating ground squirrel atrium and papillary muscle. Kardiologiya. 2008;48(11):53-60. Russian.

    CAS  Google Scholar 

  2. Kuzmin VS, Rosenschtraukh LV. Modern conceptions of the atrial fibrillation initiation. the role of the pulmonary veins myocardial sleeves. Uspekhi Fiziol. Nauk. 2010;41(4):3-26. Russian.

    CAS  Google Scholar 

  3. Burnstock G. Purinergic signalling: Its unpopular beginning, its acceptance and its exciting future. Bioessays. 2012;34(3):218-225.

    Article  CAS  PubMed  Google Scholar 

  4. Burnstock G, Pelleg A. Cardiac purinergic signalling in health and disease. Purinergic Signal. 2015;11(1):1-46.

  5. Doisne N, Maupoil V, Cosnay P, Findlay I. Catecholaminergic automatic activity in the rat pulmonary vein: electrophysiological differences between cardiac muscle in the left atrium and pulmonary vein. Am. J. Physiol. Heart Circ. Physiol. 2009; 297(1):H102-H108.

    Article  CAS  PubMed  Google Scholar 

  6. Haïssaguerre M, Jaïs P, Shah DC, Takahashi A, Hocini M, Quiniou G, Garrigue S, Le Mouroux A, Le Métayer P, Clémenty J. Spontaneous initiation of atrial fi brillation by ectopic beats originating in the pulmonary veins. N. Engl. J. Med. 1998;339(10):659-666.

    Article  PubMed  Google Scholar 

  7. Mallet ML. Proarrhythmic effects of adenosine: a review of the literature. Emerg. Med. J. 2004;21(4):408-410.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Pustovit KB, Kuzmin VS, Abramochkin D.V. Diadenosine tetra- and pentaphosphates affect contractility and bioelectrical activity in the rat heart via P2 purinergic receptors. Naunyn Schmiedebergs Arch. Pharmacol. 2016;389(3):303-313.

  9. Qu Y, Himmel HM, Campbell DL, Strauss HC. Effects of extracellular ATP on ICa, [Ca2+]i, and contraction in isolated ferret ventricular myocytes. Am. J. Physiol. 1993;264(3, Pt 1):C702-C708.

    CAS  PubMed  Google Scholar 

  10. Rankin AC, Brooks R, Ruskin JN, McGovern BA. Adenosine and the treatment of supraventricular tachycardia. Am. J. Med. 1992;92(6):655-664.

    Article  CAS  PubMed  Google Scholar 

  11. Schotten U, Verheule S, Kirchhof P, Goette A. Pathophysiological mechanisms of atrial fibrillation: a translational appraisal. Physiol. Rev. 2011;91(1):265-325.

    Article  PubMed  Google Scholar 

  12. Song Y, Belardinelli L. ATP promotes development of afterdepolarizations and triggered activity in cardiac myocytes. Am. J. Physiol. 1994;267(5, Pt 2):H2005-H2011.

    CAS  PubMed  Google Scholar 

  13. Tarasova O, Sjöblom-Widfeldt N, Nilsson H. Transmitter characteristics of cutaneous, renal and skeletal muscle small arteries in the rat. Acta Physiol. Scand. 2003;177(2):157-166.

    Article  CAS  PubMed  Google Scholar 

  14. Todorov LD, Mihaylova-Todorova S, Craviso GL, Bjur RA, Westfall DP. Evidence for the differential release of the cotransmitters ATP and norepinephrine from sympathetic nerves of the guinea-pig vas deferens. J. Physiol. 1996;496(Pt 3):731-748.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Vassort G. Adenosine 5’-triphosphate: a P2-purinergic agonist in the myocardium. Physiol. Rev. 2001;81(2):767-806.

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Human and Animal Physiology, M. V. Lomonosov Moscow State University, Moscow, Russia

    V. M. Karimova, K. B. Pustovit, D. V. Abramochkin & V. S. Kuz’min

  2. Department of Physiology, N. I. Pirogov Russian National Research Medical University, Moscow, Russia

    K. B. Pustovit, D. V. Abramochkin & V. S. Kuz’min

Authors
  1. V. M. Karimova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. B. Pustovit
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. V. Abramochkin
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. V. S. Kuz’min
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to V. M. Karimova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 162, No. 11, pp. 536-541, November, 2016

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Karimova, V.M., Pustovit, K.B., Abramochkin, D.V. et al. Effect of Purine Co-Transmitters on Automatic Activity Caused by Norepinephrine in Myocardial Sleeves of Pulmonary Veins. Bull Exp Biol Med 162, 589–593 (2017). https://doi.org/10.1007/s10517-017-3664-7

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-017-3664-7

Key Words

Search

Navigation