Skip to main content
SpringerLink
Log in

Prothrombotic effects of endothelin-2 (ET-2)

  • Immunoregulation
  • Published:
Agents and Actions Aims and scope Submit manuscript

Abstract

In this report we demonstrate that ET-2, in addition to its powerful vasoconstrictor properties and its role in hypertension, is capable of creating a hypercoagulable (prothrombotic) state. This study was facilitated by the utilization of a sensitive modified recalcification time (MRT) test that can measure coagulation at all points in the coagulation spectrum. The MRT was determined on aliquots (1 ml) of citrated blood which were added to saline (MRTS), to 10 μg of endotoxin (MRTE), and to 10 pg of ET-2 (MRT ET-2). The mean values of MRTS, MRTE, and MRT ET-2 were 4.3 ±0.8, 3.7 ± 1.0, and 3.9 ± 0.8 min, respectively. There was a statistically significant difference between MRTE vs. MRTS and MRT ET-2 vs. MRTS using the twotailedt-test (p<0.02 andp<0.005, respectively).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. C. R. Spillert and E. J. Lazaro,Contribution of the monocyte to thrombotic potential. Agents and Actions34, 28–29 (1991).

    Article  PubMed  Google Scholar 

  2. C. R. Spillert and E. J. Lazaro,Modified recalcification time: A global coagulation screening test. J. Natl. Med. Assoc. (in press).

  3. C. R. Spillert and E. J. Lazaro,Modified recalcification time monitoring of a breast cancer patient. Clin. Hemostas Rev. 6: 8 (1992).

    Google Scholar 

  4. F. J. Ferraro Jr., C. R. Spillert, K. G. Swan and E. J. Lazaro,Cold-induced hypercoagulability in vitro: A trauma connection? Am. Surg.58, 355–357 (1992).

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Surgery, UMDNJ-New Jersey Medical School, Room G505, 07103, Newark, NJ, USA

    G. W. Raff, C. R. Spillert Ph.D. (Associate Professor of Surgery), D. J. Wilson & E. J. Lazaro

  2. Department of Anatomy, UMDNJ-New Jersey Medical School, Room G505, 07103, Newark, NJ, USA

    E. J. Lazaro

Authors
  1. G. W. Raff
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. R. Spillert Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. J. Wilson
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. E. J. Lazaro
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Raff, G.W., Spillert, C.R., Wilson, D.J. et al. Prothrombotic effects of endothelin-2 (ET-2). Agents and Actions 39 (Suppl 1), C104–C105 (1993). https://doi.org/10.1007/BF01972735

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01972735

Keywords

Search

Navigation