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Contribution of the monocyte to thrombotic potential

  • Inflammatory Cells
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Abstract

The circulating monocyte exhibits the capacity to initiate and accelerate the coagulation cascade. We have devised a simple whole blood clotting assay which quantitates the monocyte's contribution of procoagulant (a marker of monocyte activation) to the clotting process and in addition, measures thein vivo activation of the cell. Citrated whole blood is added to saline and the recalcification time (RT) determined without incubation (RT control), with two hours incubation (RT saline), or added to endotoxin with incubation (RT endotoxin). The reduction in value between RT control and RT saline is a measure of monocyte activationin vivo. The reduction, in time between RT saline and RT endotoxin is a marker of monocyte activationin vitro. This simple test enables the measurement of monocyte activation and this cells contribution to the hypercoagulability described in many disease states.

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Authors and Affiliations

  1. Department of Sugery, UMDNJ-New Jersey Medical School, 185 South Orange Avenue, 07103-2757, Newark, New Jersey

    C. R. Spillert & E. J. Lazaro

  2. Anatomy, UMDNJ-New Jersey Medical School, 185 South Orange Avenue, 07103-2757, Newark, New Jersey

    E. J. Lazaro

Authors
  1. C. R. Spillert
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  2. E. J. Lazaro
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Spillert, C.R., Lazaro, E.J. Contribution of the monocyte to thrombotic potential. Agents and Actions 34, 28–29 (1991). https://doi.org/10.1007/BF01993228

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  • DOI: https://doi.org/10.1007/BF01993228

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