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Antibodies against the major core protein p24 of human immunodeficiency virus: Relation to immunological, clinical and prognostic findings

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Abstract

In 79 homosexual men positive for antibody to human immunodeficiency virus (HIV), the titer and avidity of p24 antibody was determined by an indirect ELISA and the serum tested for the presence of HIV antigen. Results were examined for a possible correlation with clinical, immunological and prognostic findings. High titers and low avidity of p24 antibodies correlated significantly with a normal pokeweed mitogen response, early lymph node changes, and an asymptomatic and stable clinical condition. In HIV antigen negative patients, low titers and high avidity of p24 antibodies correlated significantly with a progressive clinical condition. The finding of primarily high avidity antibodies against p24 antigen in patients with more advanced immunodeficiency indicates that a decline of p24 antibodies during the clinical course of HIV infection may not be explained exclusively by an increased production of viral proteins.

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Authors and Affiliations

  1. Laboratory of Tumor Virology, Fibiger Institute, Danish Cancer Society, 70 Ndr. Frihavnsgade, DK-2100, Copenhagen ø, Denmark

    B. Ørskov Lindhardt & K. Ulrich

  2. Department of Infectious Diseases, Tagensvej 20, 2200, Copenhagen N, Denmark

    J. Gerstoft

  3. Tissue Typing Laboratory, Rigshospitalet, Tagensvej 20, 2200, Copenhagen N, Denmark

    B. Hofmann & E. Dickmeiss

  4. Laboratory of Immunohistology, University Institute of Pathology, Aarhus Kommunehospital, Nørrebrogade 44, 8000, Aarhus C, Denmark

    G. Pallesen

  5. Department of Infectious Diseases, Hvidovre Hospital, Kettegaard Alle 30, 2650, Hvidovre, Denmark

    L. Mathiesen

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  1. B. Ørskov Lindhardt
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Ørskov Lindhardt, B., Gerstoft, J., Hofmann, B. et al. Antibodies against the major core protein p24 of human immunodeficiency virus: Relation to immunological, clinical and prognostic findings. Eur. J. Clin. Microbiol. Infect. Dis. 8, 614–619 (1989). https://doi.org/10.1007/BF01968139

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