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Characteristics of Circulating Immune Complexes in HIV-Infected Patients with Different Viral Load

  • IMMUNOLOGY AND MICROBIOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

Serum concentration of antiviral antibodies was measured in HIV-infected patients with different viral load. It was found that higher concentrations of HIV-antigens correspond to higher titer of antiviral antibodies. Circulating immune complexes were isolated from patients’ serum to estimate their size and immunoglobulin composition. High levels of small IgG- and IgM-containing complexes were identified in HIV-infected patients. In patients receiving antiretroviral treatment, the content of these complexes was significantly lower than in patients with high HIV load. This attests to positive role of specific therapy in preventing immune complex-associated pathology in HIV patients.

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Authors and Affiliations

  1. Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences, Ekaterinburg, Russia

    L. B. Korolevskaya & K. V. Shmagel

  2. Regional Center on Prophylaxis and Combating of AIDS and Infection Diseases, Perm’, Russia

    L. B. Korolevskaya & N. G. Shmagel

Authors
  1. L. B. Korolevskaya
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  2. K. V. Shmagel
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  3. N. G. Shmagel
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Corresponding author

Correspondence to L. B. Korolevskaya.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 159, No. 4, pp. 460-463, April, 2015

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Korolevskaya, L.B., Shmagel, K.V. & Shmagel, N.G. Characteristics of Circulating Immune Complexes in HIV-Infected Patients with Different Viral Load. Bull Exp Biol Med 159, 469–471 (2015). https://doi.org/10.1007/s10517-015-2994-6

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  • DOI: https://doi.org/10.1007/s10517-015-2994-6

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