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Further support for the postsynaptic action of substance P and its blockade with baclofen in neurons of the guinea-pig hypothalamus in vitro

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Summary

Effects of substance P on neurons of the guinea-pig hypothalamus in vitro and antagonism between substance P and baclofen were investigated. Substance P increased the firing rate of neurons in the medium containing 0 mM Ca2+ and 12 mM Mg2+. The excitatory action of stubstance P was antagonized by a low dose of baclofen whereas that of acetylcholine was not antagonized even by much higher doses of baclofen.

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Authors and Affiliations

  1. Department of Pharmacology, Faculty of Medicine, Kyushu University, 812, Fukuoka, Japan

    N. Ogata & H. Abe

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  1. N. Ogata
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  2. H. Abe
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Additional information

Acknowledgments. We thank Prof. M. Otsuka for providing baclofen and for helpful suggestions, Prof. H. Kuriyama for valuable discussions, Dr. M. Ohara for critical reading of the manuscript, and Ciba-Geigy (Japan) for providing baclofen.

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Ogata, N., Abe, H. Further support for the postsynaptic action of substance P and its blockade with baclofen in neurons of the guinea-pig hypothalamus in vitro. Experientia 37, 759–761 (1981). https://doi.org/10.1007/BF01967965

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  • DOI: https://doi.org/10.1007/BF01967965

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