The actions of the nootropes noopept and piracetam on depression of the acetylcholine-induced current in a cellular analog of habituation were studied. Mathematical modeling of experimental curves and their analysis using previously obtained results on the effects of inhibitors of different protein kinases and protein phosphatases on acquisition of depression of the acetylcholine-induced current in a cellular analog of habituation clarified the intracellular processes and targets on which these agents act.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Antipova, T. A., Nikolaev, S. V., Ostrovskaya, et al., “Dipeptide piracetam analogue noopept improves viability of hippocampal HT-22 neurons in the glutamate toxicity model,” Bull. Exp. Biol. Med., 161, No. 1, 58–60 (2016).
Bravo-Martínez, J., Arenas, I., Vivas, O., et al., “A novel CaV2.2 channel inhibition by piracetam in peripheral and central neurons,” Exp. Biol. Med., 237, No. 10, 1209–1218 (2012).
Gudasheva, T. A. and Skoldinov, A. P., “A strategy for creating dipeptide neuropsychotropic drugs,” Eksperim. Klin. Farmakol., 66, No. 2, 15–19 (2003).
Gudasheva, T. A., Voronina, T. A., Ostrovskaya, R. U., et al., “Synthesis and antiamnestic activity of a series of N-acylprolyl-containing dipeptides,” Eur. J. Med. Chem., 31, No. 2, 151–157 (1996).
Ierusalimskii, V. N., Zakharov, I. S., Palikhova, T. A., and Balaban, P. M., “The nervous system and mapping of neurons in the gastropod mollusk Helix lucorum,” Zh. Vyssh. Nerv. Deyat., 42, No. 6, 1075–1089 (1992).
Leuner, K., Kurz, C., Guidetti, G., et al., “Improved mitochondrial function in brain aging and Alzheimer disease – the new mechanism of action of the old metabolic enhancer piracetam. Review article,” Front Neurosci., 4, article 44 (2010), DOI: 10.3389/fnins.2010.00044.
Makhnovskii, D. A., Murzina, G. B., Tret’yakova, M. S., and Pivovarov, A. S., “The role of serine/threonine and tyrosine protein kinases in depression of cholinosensitivity in common snail neurons in a cellular analog of habituation,” Zh. Vyssh. Nerv. Deyat., 61, No. 4, 459–475 (2011).
Malykh, A. G. and Reza Sadaie, M., “Piracetam and piracetam-like drugs. From basic science to novel clinical applications to CNS disorders,” Drugs, 70, No. 3, 287–312 (2010).
Müller, W. E., Koch, S., Scheuer, K., et al., “Effects of piracetam on membrane fluidity in the aged mouse, rat, and human brain,” Biochem. Pharmacol., 53, No. 2, 135–140 (1997).
Murzina, G. B. and Pivovarov, A. S., “Noopept modulation of the acetylcholine-induced influx current in common snail neurons,” Biofizika, 64, No. 3, 507–514 (2019).
Ostrovskaya, R. U., Mirzoev, T. Kh., Firova, F. A., et al., “Behavioral and electrophysiological analysis of the cholinopositive action of nootropic acetylproline dipeptide GVS-111,” Eksperim. Klin. Farmakol., 64, No. 2, 11–14 (2001).
Ostrovskaya, R. U., Vahitova, J. V., Salimgareeva, M. H., et al., “Noopept stimulates the expression of NGF and BDNF in rat hippocampus,” Bull. Exp. Biol. Med., 14, No. 2, 334–337 (2008).
Pilch, H. and Muller, W. E., “Piracetam elevates muscarinic cholinergic receptor density in the frontal cortex of aged but not of young mice,” Psychopharmacology, 9, No. 4, 74–78 (1988).
Pivovarov, A. S., Murzina, G. B., Makhnovskii, D. A., et al., “The role of myosins in depression of the sensitivity of common snail neurons in a cellular analog of habituation,” Zh. Vyssh. Nerv. Deyat., 63, No. 4, 470–478 (2013a).
Pivovarov, A. S., Murzina, G. B., Makhnovsky, D. A., et al., “Mobility of acetylcholine receptors in command Helix lucorum neurons in a cellular analog of habituation,” Invert. Neuroscientist, 13, No. 2, 135–150 (2013).
Pivovarov, A. S., Murzina, G. B., Tret’yakova, M. S., and Makhnovskii, D. A., “The role of serine/threonine and tyrosine protein phosphatases in common snail command neurons in a cellular analog of habituation,” Zh. Vyssh. Nerv. Deyat., 63, No. 2, 256–268 (2013b).
Pivovarov, A. S., Murzina, G. B., Vasilyeva, N. A., and Makhnovskii, D. A., “The role of actin microfilaments in depression of acetylcholine-induced currents in common snail neurons in a cellular analog of habituation,” Zh. Vyssh. Nerv. Deyat., 62, No. 2, 222–232 (2012).
Pugsley, T. A., Shih, Y. H., Coughenoor, L., and Stewart, S. F., “Some neurochemical properties of pramiracetam (CI-879), a new cognition enhancing agent,” Drug Dev. Res., 2, 407–420 (1983).
Razumovskaya, M. A., Murzina, G. B., Ostrovskaya, R. U., and Pivovarov, A. S., “Noopept and piracetam modulation of nicotinic receptors in common snail neurons,” Zh. Vyssh. Nerv. Deyat., 68, No. 4, 537–548 (2018).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Zhurnal Vysshei Nervnoi Deyatel’nosti imeni I. P. Pavlova, Vol. 70, No. 1, pp. 125–132, January–February, 2020.
Rights and permissions
About this article
Cite this article
Pivovarov, A.S., Murzina, G.B. & Vasilyeva, N.V. Effects of Noopept and Piracetam on Depression of the Acetylcholine-Induced Current in Common Snail Command Neurons. Neurosci Behav Physi 50, 1012–1017 (2020). https://doi.org/10.1007/s11055-020-01000-2
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11055-020-01000-2