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Comparative effects of oxatomide on the release of histamine from rat peritoneal mast cells

  • Histamine and Kinins
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Abstract

Oxatomide inhibits the release of histamine from rat peritoneal mast cells in vitro induced by C 48/80, antigen, anti-IgE and ionophore A 23 187, without effect on non-specific release byn-decylamine. Its effect is concentration- and pH-dependent and decreases with increasing extracellular Ca2+-concentrations. Prolonged incubation does not enhance the inhibition, which is lost after one single wash-out. Aminophylline and isoproterenol are not potentiated by oxatomide. The present study points to an effect of oxatomide on a Ca2+-dependent process at the level of cell membrane common to antigen, C 48/80 and ionophore A 23 187.

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Authors and Affiliations

  1. Laboratories of Haematology and Cell Biology, Janssen Pharmaceutica Research Laboratories, B-2340, Beerse, Belgium

    F. De Clerck, J. Van Reempts & M. Borgers

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  1. F. De Clerck
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  2. J. Van Reempts
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  3. M. Borgers
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De Clerck, F., Van Reempts, J. & Borgers, M. Comparative effects of oxatomide on the release of histamine from rat peritoneal mast cells. Agents and Actions 11, 184–192 (1981). https://doi.org/10.1007/BF01967612

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  • DOI: https://doi.org/10.1007/BF01967612

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