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Serotoninergic modulation of mesolimbic and frontal cortical dopamine neurons

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Summary

Potentiation of the effect of haloperidol on dopamine metabolism by the 5-HT uptake inhibitor CGP 6085 A, and antagonism of this effect by the 5-HT antagonist mianserin were observed in the mesolimbic area and the frontal cortex of the rat brain. A similar effect was reported earlier in the corpus striatum. This suggests that serotoninergic modulation of dopamine neurons is a generally-occurring phenomenon in the brain.

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References

  1. W. Kostowski, Pol. J. Pharmac. Pharm.27, Suppl. 15 (1975).

  2. R. Samanin and S. Garattini, Life Sci.17 1201 (1975).

    Article  CAS  PubMed  Google Scholar 

  3. P. C. Waldmeier, Eur. J. Pharmac.60, 315 (1979).

    Article  CAS  Google Scholar 

  4. P. C. Waldmeier and A. Delini-Stula, Eur. J. Pharmac.55, 363 (1979).

    Article  CAS  Google Scholar 

  5. J. J. Balsara, J. H. Jadhav and A. G. Chandorkar, Psychopharmacology62, 67 (1979).

    Article  CAS  PubMed  Google Scholar 

  6. C. J. Carter and C. J. Pycock, Br. J. Pharmac.60, 267P (1977).

  7. B. Costall, D. H. Fortune, R. J. Naylor, C. D. Marsden and C. Pycock, Neuropharmacology14, 859 (1975).

    Article  CAS  PubMed  Google Scholar 

  8. W. Kostowski, W. Gumulka and A. Czlonzowski, Brain Res.48, 443 (1972).

    Article  CAS  PubMed  Google Scholar 

  9. C. J. Carter and C. J. Pycock, Naunyn-Schmiedeberg's Arch. Pharmac.308, 51 (1979).

    Article  CAS  Google Scholar 

  10. J. Korf, L. Grasdijk and B. H. C. Westerink, J. Neurochem.26, 579 (1976).

    Article  CAS  PubMed  Google Scholar 

  11. R. H. Roth, L. C. Murrin and J. R. Walters, Eur. J. Pharmac.36, 163 (1976).

    Article  CAS  Google Scholar 

  12. P. C. Waldmeier and L. Maître, J. Neurochem.27, 589 (1976).

    Article  CAS  PubMed  Google Scholar 

  13. B. H. C. Westerink and J. Korf, Eur. J. Pharmac.38, 281 (1976).

    Article  CAS  Google Scholar 

  14. L. J. Felice, C. S. Bruntlett and P. T. Kissinger, J. Chromat.143, 407 (1977).

    Article  CAS  Google Scholar 

  15. L. J. Felice and P. T. Kissinger, Analyt. Chem.48, 794 (1976).

    Article  CAS  Google Scholar 

  16. G. Curzon and A. R. Green, Br. J. Pharmac.39, 653 (1970).

    Article  CAS  Google Scholar 

  17. C. W. Dunnett, Biometrics20, 483 (1964).

    Article  Google Scholar 

  18. B. B. Vargaftig, J. L. Coignet, C. J. de Vos, H. Grijsen and I. L. Bonta, Eur. J. Pharmac.16, 336 (1971).

    Article  CAS  Google Scholar 

  19. P. C. Waldmeier, P. A. Baumann, M. Wilhelm, R. Bernasconi and L. Maître, Eur. J. Pharmac.46, 387 (1977).

    Article  CAS  Google Scholar 

  20. P. C. Waldmeier, P. A. Baumann and L. Maître, J. Pharmac. exp. Ther.211, 42 (1979).

    CAS  Google Scholar 

  21. P. A. Baumann and L. Maître, Naunyn-Schmiedeberg's Arch. Pharmac.300, 31 (1977).

    Article  CAS  Google Scholar 

  22. B. E. Leonard, Psychopharmacologia36, 221 (1974).

    Article  CAS  PubMed  Google Scholar 

  23. B. H. C. Westerink and J. Korf, Eur. J. Pharmac.33, 31 (1975).

    Article  CAS  Google Scholar 

  24. D. A. V. Peters, M. Filczewski and I. M. Mazurkiewicz-Kwilecki, Biochem. Pharmac.21, 2282 (1972).

    Article  CAS  Google Scholar 

  25. A. Tagliamonte, P. Tagliamonte, G. U. Corsini, G. P. Mereu and G. L. Gessa, J. Pharm. Pharmac.25, 101 (1973).

    Article  CAS  Google Scholar 

  26. M. C. Scally, I. Ulus and R. J. Wurtman, J. neural Transm.41, 1 (1977).

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Departement Forschung, Division Pharma, Ciba-Geigy AG, CH-4002, Basel, Switzerland

    P. C. Waldmeier

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  1. P. C. Waldmeier
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Waldmeier, P.C. Serotoninergic modulation of mesolimbic and frontal cortical dopamine neurons. Experientia 36, 1092–1094 (1980). https://doi.org/10.1007/BF01965988

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  • DOI: https://doi.org/10.1007/BF01965988

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