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Effects of propafenone on TEA-induced action potentials in vascular smooth muscle of canine coronary arteries

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Summary

The Ca++-dependent, TEA-induced action potential is blocked by propafenone in a dose-dependent manner. Such results suggests that in coronary arterial smooth muscle one mechanism of action of propafenone is to inhibit Ca++ inward current.

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Authors and Affiliations

  1. Department of Physiology, East Tennessee State University, College of Medicine, 37601, Johnson City, Tennessee, USA

    D. R. Harder & L. Belardinelli

  2. Department of Physiology, University of Virginia, School of Medicine, 22903, Charlottesville, Virginia, USA

    D. R. Harder & L. Belardinelli

Authors
  1. D. R. Harder
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  2. L. Belardinelli
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Additional information

This research was supported by a grant from the Tennessee Affiliate of the American Heart Association and VA grant No. 1A (74)111-430100). The authors wish to thank Dr Gerhard Pfennigsdorf for supplying us with propafenone. We also wish to thank Ms Penny Williams for her technical assistance.

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Harder, D.R., Belardinelli, L. Effects of propafenone on TEA-induced action potentials in vascular smooth muscle of canine coronary arteries. Experientia 36, 1082–1083 (1980). https://doi.org/10.1007/BF01965982

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