Summary
5,6-Dihydroxytryptamine, a serotonin depletor, infused directly into the anterior hypothalamus of rat's brain, produced an increase in both heat production and heat loss (as indicated by changes in peripheral circulation) at temperatures of 8, 15 and 22°C. The rectal temperature of these treated rats remained constant.
Similar content being viewed by others
References
A. Williams and G. P. Moberg, Comp. Biochem. Physiol.51, 67 (1975).
R. D. Myers, Brain Res.94, 491 (1975).
M. B. Waller, R. D. Myers and G. E. Martin, Neuropharmacology15, 61 (1976).
M. T. Lin, I. H. Pang, S. I. Chern and W. Y. Chia, Am. J. Physiol.235, R41 (1978).
M. T. Lin and J. T. Stitt, Physiologist, Wash.19, 271 (1976).
J. De Groot, The Rat Forebrain in Stereotaxic Coordinates. North-Holland Publ., Amsterdam 1959.
M. T. Lin, W. Y. Chia, C. T. Tsai and T. H. Yin, Experientia34, 756 (1978).
H. G. Baumgarten, L. Lachenmayer and H. G. Schlossberger, Z. Zellforsch.125, 553 (1972).
J. T. Stitt and J. D. Hardy, J. appl. Physiol.31, 48 (1971).
M. T. Lin, J. Pharmac. exp. Ther.204, 39 (1978).
J. T. Stitt, J. D. Hardy and J. A. J. Stolwijk, Am. J. Physiol.227, 622 (1974).
J. Bligh, W. H. Cottle and M. Maskrey, J. Physiol.212, 377 (1971).
R. F. Hellon, Pharmac. Rev.26, 289 (1975).
Author information
Authors and Affiliations
Additional information
This work was supported by grants from National Science Council of Taiwan and J. Aron Charitable Foundation (USA). The author is grateful to Dr C. Y. Chai and Mr C. C. Wei for their support.
Rights and permissions
About this article
Cite this article
Lin, M.T. Effects of hypothalamic injections of 5,6-dihydroxytryptamine on thermoregulation in rats. Experientia 35, 359–361 (1979). https://doi.org/10.1007/BF01964352
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01964352