We studied the responses of the organism to administration of autonomic transmitters in different doses: epinephrine (from 0.0000001 to 300 μg per 100 g body weight), serotonin (25, 50, 250, and 500 μg), and their combinations. The concentrations of biogenic amines in the blood and hypothalamus and parameters of oxidative and antioxidant systems, immune status, and blood coagulation and anticoagulation systems were analyzed. Cyclic dose-dependent variations in the levels of transmitters were revealed that dynamically changed their properties of syntoxins and catatoxins.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 158, No. 12, pp. 665-668, December, 2014
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Zilov, V.G., Khadartsev, A.A., Morozov, V.N. et al. Effect of Different Doses of Transmitters on the Mechanisms of Adaptation. Bull Exp Biol Med 158, 707–710 (2015). https://doi.org/10.1007/s10517-015-2842-8
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DOI: https://doi.org/10.1007/s10517-015-2842-8