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Disparate Na+-requirement of taurocholate and indocyanine green uptake by isolated hepatocytes

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Summary

Uptake of both taurocholate and indocyanine green (ICG) by isolated rat hepatocytes was saturable and obeyed Michaelis-Menten kinetics. Only uptake of taurocholate exhibited Na+-dependence, a phenomenon compatible with active membrane transport. These findings suggest that the mechanisms responsible for hepatocellular uptake of bile acids and anionic dyes differ fundamentally.

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Authors and Affiliations

  1. Department of Clinical Pharmacology, University of Berne, Murtenstrasse 35, CH-3010, Berne, Switzerland

    E. Minder & G. Paumgartner

Authors
  1. E. Minder
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  2. G. Paumgartner
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Additional information

This work was supported by the Swiss National Science Foundation.

The authors thank Mr Th. Weber for technical assistance.

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Minder, E., Paumgartner, G. Disparate Na+-requirement of taurocholate and indocyanine green uptake by isolated hepatocytes. Experientia 35, 888–890 (1979). https://doi.org/10.1007/BF01955131

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