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Effects of electrical stimulation of periaqueductal gray matter on evoked potentials recorded in the primary somesthetic cortical areas of the rat

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Summary

The influence of focal electrical stimulation of PGM on primary cortical evoked potentials elicted by nociceptive peripheral stimulation was studied in anaesthetized and conscious rats. This analgesic electrical stimulation produces an abolition of cortical responses during its application and a significant decrease of the positive and negative amplitude waves after interruption of PGM electrical stimulation. Since these effects were observed in animals under barbiturate anesthesia and in conscious rats, they are interpreted as a supraspinal action on the primary pain pathway.

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Authors and Affiliations

  1. Laboratorio de Biofísica y Neurofisiología, Instituto de Nutrición y Tecnología de los Alimentos and Facultad de Medicina Sur, Universidad de Chile, Casilla 15138, Santiago 11, Santiago, Chile

    A. Hernández, S. Ruiz, H. Pérez & R. Soto Moyano

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  1. A. Hernández
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  2. S. Ruiz
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  3. H. Pérez
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  4. R. Soto Moyano
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Additional information

We are grateful to Dr. O. Brunser for his help in the preparation of the manuscript.

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Hernández, A., Ruiz, S., Pérez, H. et al. Effects of electrical stimulation of periaqueductal gray matter on evoked potentials recorded in the primary somesthetic cortical areas of the rat. Experientia 33, 1049–1051 (1977). https://doi.org/10.1007/BF01945963

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  • DOI: https://doi.org/10.1007/BF01945963

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