Summary
Streptozotocin-diabetes in rats leads to a decrease of cytochrome P-450 UT-A (the major form in control rats) and an increase of cytochrome P-450 PB-B (the major one induced by phenobarbital treatment) in liver microsomes. The increased benzphetamine-N-demethylase activity can be related to the induction of cytochrome P-450 PB-B.
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Rouer, E., Beaune, P. & Leroux, J.P. Immunoquantitation of some cytochrome P-450 isozymes in liver microsomes from streptozotocin-diabetic rats. Experientia 42, 1162–1163 (1986). https://doi.org/10.1007/BF01941293
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DOI: https://doi.org/10.1007/BF01941293