Skip to main content
SpringerLink
Log in

Effects of 1-alkyl-1,2,3,4-tetrahydrocarbazole-1-ethanamines and related compounds, potential antidepressants, on biogenic amine uptake mechanisms

  • Published:
Experientia Aims and scope Submit manuscript

Summary

A new series of compounds structurally related to the potential antidepressant tandamine, i.e., the 1-alkyl-1,2,3,4-tetrahydrocarbazole-1-ethanamines, inhibit the noradrenaline uptake mechanism and are relatively ineffective in inhibiting the serotonin uptake mechanism in vivo. The potency of the most effective compound (9-ethyl-N,N, 1-trimethyl-1,2,3,4-tetrahydrocarbazole is similar to that of desimipramine and is of potential use in the treatment of endogenously depressed patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. W. Lippmann andT. A. Pugsley, Pharmacologist17, 258 (1975).

    Google Scholar 

  2. W. Lippmann andT. A. Pugsley, Biochem. Pharmac.25, 1179 (1976).

    Article  CAS  Google Scholar 

  3. T. A. Pugsley andW. Lippmann, Psychopharmacologia47., 33 (1976).

    Article  CAS  Google Scholar 

  4. I. Jirkovsky, L. G. Humber, K. Voith, M.-P. Charest, T. A. Pugsley andW. Lippmann, 169th ACS National Meeting, Philadelphia, Pa., April 1975, Abstr. Med. 34.

  5. J. Glowinski andJ. Axelrod, Pharmac. Rev.,18, 775 (1966).

    CAS  Google Scholar 

  6. A. Carlsson, J. Jonason, M. Lindqvist andK. Fuxe, Brain Res.12, 456 (1969).

    Article  CAS  PubMed  Google Scholar 

  7. A. A. Asselin, L. G. Humber, J. Komlossy andM.-P. Charest, J. Med. Chem. (in press).

  8. W. Lippmann, J. Med.2, 250 (1971).

    CAS  PubMed  Google Scholar 

  9. A. Carlsson, H. Corrodi, K. Fuxe andT. Hökfelt, Eur. J. Pharmac.5, 357 (1969).

    Article  CAS  Google Scholar 

  10. A. Carlsson, H. Corrodi, K. Fuxe andT. Hökfelt, Eur. J. Pharmac.5, 367 (1969).

    Article  CAS  Google Scholar 

  11. L. G. Whitby, J. Axelrod andH. Weil-Malherbe, J. Pharmac. exp. Ther.132, 193 (1961).

    CAS  Google Scholar 

  12. U. S. Von Euler andI. Floding, Acta Physiol. scand.33, Suppl.118, 45–47 (1955).

    Google Scholar 

  13. R. Laverty andK. M. Taylor, Ann. Biochem.22, 269 (1968).

    Article  CAS  Google Scholar 

  14. J. Bruinvels, Br. J. Pharmac.42, 281 (1971).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Biochemical Pharmacology Department, Ayerst Research Laboratories, Box 6115, H3C 3JI, Montreal, Quebec, Canada

    T. A. Pugsley & W. Lippmann

Authors
  1. T. A. Pugsley
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. W. Lippmann
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

The authors acknowledge the technical assistance of Mrs J. Farnsworth, Mrs B. Gut and Mr J. Lacasse.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Pugsley, T.A., Lippmann, W. Effects of 1-alkyl-1,2,3,4-tetrahydrocarbazole-1-ethanamines and related compounds, potential antidepressants, on biogenic amine uptake mechanisms. Experientia 33, 57–59 (1977). https://doi.org/10.1007/BF01936753

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01936753

Keywords

Search

Navigation