Summary
The activity of cytochrome oxidase greatly decreases in the organs of rats treated with D-penicillamine for 20 days (30 mg/100 g/day). Although the drug does not affect cytochrome oxidase in vitro, it readily reduces oxidized cyt. c.
Similar content being viewed by others
References
J. M. Walshe, Am. J. Med.21, 478 (1956).
K. F. Swaiman and D. G. Flager, Pediatrics48, 639 (1971).
L. F. Vitale, A. Rosalinas-Bailon, D. Folland, J. F. Brennan and B. McCormick, J. Pediat.83, 1041 (1973).
V. Albergoni, A. Cassini, N. Favero and G. P. Rocco, Biochem. Pharmac.24, 1131 (1975).
C. F. Mills and A. C. Dalgarno, in: Trace Elements Metabolism in Animals, p. 456. Ed. C. F. Mills. Livingstone, Edinburg and London 1970.
D. E. Green and D. M. Ziegler, in: Methods in Enzymology. Ed. S. P. Colowick and N. O. Kaplan, p. 416. Academic Press., New York 1963.
L. Smith, in: Methods of Biochemical Analysis, p. 427, Ed. D. Glick, Wiley, New York 1963
T. J. Yonetani, J. biol. Chem.240, 4509 (1965).
W. Evans, Physiol. Rev.535, 53 (1973).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Albergoni, V., Favero, N. & Ghiretti, F. The action of D-penicillamine on cytochrome oxidase in vivo and in vitro. Experientia 33, 17–18 (1977). https://doi.org/10.1007/BF01936726
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01936726