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Formation of N-glucuronide of desmethylimipramine in the dog

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Zusammenfassung

Nach Verbreichung von Imipramin oder Desmethylimipramin bilden Hunde neben den bekannten Metaboliten Konjugate von Desmethylimipramin (und in kleineren Mengen von Desdimethylimipramin). Die Befunde sprechen für aliphatische N-Glukuronide und damit für einen bisher kaum beschriebenen Typus von Arzneimittelmetaboliten.

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Authors and Affiliations

  1. Medizinisch-chemisches Institut, University of Bern, CH-3012, Bern, Switzerland

    M. H. Bickel, R. Minder & C. di Francesco

Authors
  1. M. H. Bickel
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  2. R. Minder
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  3. C. di Francesco
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Additional information

Acknowledgment. We are indebted to the Swiss National Science Foundation for support and to Dr.R. Preisig for the use of facilities at the Institute of Clinical Pharmacology, University of Berne.

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Bickel, M.H., Minder, R. & di Francesco, C. Formation of N-glucuronide of desmethylimipramine in the dog. Experientia 29, 960–961 (1973). https://doi.org/10.1007/BF01930401

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