Skip to main content

Advertisement

SpringerLink
Log in

The identification of chlorpromazine metabolites in human blood by gas liquid chromatography

  • Specialia
  • Studiorum Progressus
  • Published:
Experientia Aims and scope Submit manuscript

Zusammenfassung

Chlorpromazin und 5 sciner Metaboliten wurden gaschromatographisch in menschlichem Plasma identifiziert. Zwei dieser Metaboliten wurden auch in Erythrozyten aufgefunden. Die Blutproben wurden von Paticnten genommen, welche täglich 100–250 mg Chlorpromazin erhielten. Chlorpromazin und die nicht konjugierten Metabolite scheinen vom Plasma innerhalb weniger Stunden nach Verabreichung einer Dosis Chlorpromazin zu verschwinden. Die gebundenen Metabolite konnten jedoch zu jeder Zeit nachgewiesen werden. Das metabolische Bild kann von einem Patienten zum anderen wechseln.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. J. Delay, P. Deniker andJ. M. Hari, Annls méd.-psychol.2, 112 (1952).

    Google Scholar 

  2. C. L. Huang andB. H. Ruskin, J. nerv. ment. Dis.139, 381 (1964).

    Article  CAS  Google Scholar 

  3. N. P. Salzman andB. B. Brodie, J. Pharmac. exp. Ther.46, 108 (1956).

    Google Scholar 

  4. J. L. Driscoll, H. F. Martin andB. J. Gudzinowicz, J. Gas Chromatography2, 109 (1964).

    Article  CAS  Google Scholar 

  5. R. M. Rose, A. DiMascio andG. L. Klerman, J. psychiat. Res.2, 299 (1964).

    Article  CAS  Google Scholar 

  6. D. E. Johnson, C. F. Rodriguez andH. P. Burchfield, Biochem. Pharmac.14, 1456 (1965).

    Google Scholar 

  7. C. F. Rodriguez andD. E. Johnson, Life Sci.5, 1283 (1966).

    Article  CAS  Google Scholar 

  8. Biochemical Application of Gas Chromatography (Ed.H. A. Szymanski, Plenum Press, N.Y. 1964).

    Google Scholar 

  9. E. J. Bonelli andK. P. Dimick, inLectures on Gas Chromatography-1964 (EdsL. R. Mattick andH. A. Szymanski; Plenum Press, N.Y. 1965), p. 15.

    Google Scholar 

  10. B. J. Gudzinowicz, J. Gas Chromatography4, 110 (1966).

    Article  CAS  Google Scholar 

  11. W. Hammer andF. Sjöqvist, Life Sci.6, 1895 (1967).

    Article  CAS  Google Scholar 

  12. D. E. Green, I. S. Forrest, F. M. Forrest andM. T. Serra, Expl Med. Surg.23, 278 (1965).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Toxicology, Swedish Medical Research Council, Karolinska Institutet, Stockholm 60, Sweden

    C.-G. Hammar & B. Holmstedt

Authors
  1. C.-G. Hammar
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. B. Holmstedt
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hammar, CG., Holmstedt, B. The identification of chlorpromazine metabolites in human blood by gas liquid chromatography. Experientia 24, 98–100 (1968). https://doi.org/10.1007/BF02136820

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02136820

Keywords

Search

Navigation