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Laktationshemmende Wirkung von N-[d-6-Methyl-8-isoergolin-I-yl]-N′, N′-diäthylharnstoff (VÚFB-6638)

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Summary

The inhibiting effect of orally administered N-[d-6-methyl-8-isoergolin-I-yl], N′, N′-diethylurea (VÚFB-6638) on the production of milk was found in rats. The inhibition of lactation was ascertained through the observation of the daily weightgains of the suckled puppies (ED50=0.112 mg/kg/day) and through the observation of the presence of milk in the stomach of these puppies, as seen through their abdomen wall (0.084 mg/kg/day). This inhibition could be abolished with exogenous prolactin, which gives evidence that the drug studied acts via the endocrine system.

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Authors and Affiliations

  1. Forschungsinstitut für Pharmazie und Biochemie, Kouřimská 17, CSSR-130 60, Praha 3, Czech Republic

    M. Aušková, K. Řežábek, V. Zikán & M. Semonský

Authors
  1. M. Aušková
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  2. K. Řežábek
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  3. V. Zikán
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  4. M. Semonský
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Additional information

Für die technische Assistenz danken wir FrauM. Kommersová und FrauV. Mašitová.

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Aušková, M., Řežábek, K., Zikán, V. et al. Laktationshemmende Wirkung von N-[d-6-Methyl-8-isoergolin-I-yl]-N′, N′-diäthylharnstoff (VÚFB-6638). Experientia 30, 393–394 (1974). https://doi.org/10.1007/BF01921682

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  • DOI: https://doi.org/10.1007/BF01921682

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