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Untersuchungen zum Einfluß des Insulins auf die intestinale Resorption beim Menschen

II. Der Einfluß endogenen und intravenös injizierten Insulins auf die Resorption

The effect of insulin on the intestinal absorption in man

II. The Effect of Endogenous and Intravenously Injected Insulin on the Absorption

  • Published:
Research in Experimental Medicine

Summary

The influence of insulin on the intestinal absorption of glucose, water, sodium and potassium was investigated in man using a triple lumen tube technique. After an absorption period of 60 min 1 g of tolbutamide was injected in order to stimulate endogenous insulin secretion. Alternatively 20 units of regular insulin were applied intravenously. Thereafter absorption was studied over 4 periods of 15 min duration.

Results:

  1. 1.

    In healthy subjects the absorption of glucose water, sodium and potassium was decreased after the injection of tolbutamide as well as after the injection of insulin.

  2. 2.

    The decrease in absorption was also demonstrable when the insulin induced reduction of blood sugar levels was abolished by intravenous glucose infusion.

  3. 3.

    In insulin dependent diabetics there was no decrease in absorption after injection of tolbutamide. This was due to the unability to secrete insulin. On the other hand a decrease in absorption occurred if insulin was applied in insulin dependent diabetics.

These results demonstrate that the absorption of glucose, water, sodium and potassium from the human intestine is reduced by insulin.

Zusammenfassung

Der Einfluß von Insulin auf die Resorption von Glucose, Wasser, Natrium und Kalium wurde mittels der segmentalen Dünndarmperfusion mit einer dreilumigen Sonde untersucht. Nach Messung der Resorption über zwei 30 min-Perioden wurden den Probanden 1,0 g Tolbutamid (Rastinon®) bzw. 20 IE Insulin (Actrapid®) intravenös injiziert und danach die Resorption über vier 15 min-Perioden bestimmt.

Ergebnisse

  1. 1.

    Stoffwechselgesunde zeigten sowohl nach Injektion von Tolbutamid und dadurch induzierter Erhöhung des Seruminsulinspiegels als auch nach Insulininjektion eine signifikante Minderung der Resorption.

  2. 2.

    Diese Resorptionsminderung war auch nachweisbar, wenn Glucose zur Verhinderung des Blutzuckerabfalls unmittelbar nach der Insulininjektion infundiert wurde.

  3. 3.

    Insulinbedürftige Diabetiker lassen nach der Injektion von Tolbutamid — offenbar infolge fehlender Insulinsekretion — keine Resorptionsänderungen erkennen, zeigen aber eine Transportminderung nach Insulininjektion.

Diese Befunde belegen, daß die Glucose-, Wasser-, Natrium- und Kaliumresorption im menschlichen Dünndarm durch Insulin reduziert wird.

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Authors and Affiliations

  1. Medizinische Klinik der Universität, Mannkopffstraße 1, D-3550, Marburg an der Lahn, Bundesrepublik Deutschland

    H. Gottesbüren, E. Schmitt, H. Menge, R. Bloch, H. Lorenz-Meyer & E. O. Riecken

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  1. H. Gottesbüren
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  2. E. Schmitt
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  3. H. Menge
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  4. R. Bloch
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  5. H. Lorenz-Meyer
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  6. E. O. Riecken
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Gottesbüren, H., Schmitt, E., Menge, H. et al. Untersuchungen zum Einfluß des Insulins auf die intestinale Resorption beim Menschen. Res. Exp. Med. 161, 262–271 (1973). https://doi.org/10.1007/BF01851450

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  • DOI: https://doi.org/10.1007/BF01851450

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