Abstract
During the past 12 years, ten cases of globoidcell leukodystrophy (GLD) have been followed up: seven of these patients were affected by the late infantile form. The authors point out the clinical aspects and the course of these patients and stress the high frequency of this form of GLD in Sicily.
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Kobayashi T, Shinnoh N, Goto I, Kuroiwa Y (1985) Hydrolysis of galactosylceramide is catalized by two genetically distinct acid beta galactosidases. J Biol Chem 260:14982–14987
Kobayashi T, Goto I, Yamanaka T, Suzuki Y, Nakano T, Suzuki K (1988) Infantile and fetal globoid cell leukodystrophy: analysis of galactosylceramide and galactosyl-sphingosine. Ann Neurol 24:517–522
Loonen MCB, Van Diggelen OP, Janse HC, Kleijer JW, Arts WFM (1985) Late onset globoid cell leukodystrophy (Krabbe's disease). Clinical and genetic delineation of 2 forms and their relation to the early-infantile form. Neuropediatrics 16:137–142
Lyon G, Hagberg B (1987) Late onset Krabbe's disease. Meeting of the European Federation of Child Neurology Societies, Hyvinkää, Rantasipi 1987
Miyatake T, Suzuki K (1972) Globoid cell leukodystrophy: additional deficiency of psychosine galactosidase. Biochem Biophys Res Commun 48:538–543
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Fiumara, A., Pavone, L., Siciliano, L. et al. Late-onset globoid cell leukodystrophy. Child's Nerv Syst 6, 194–197 (1990). https://doi.org/10.1007/BF01850970
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DOI: https://doi.org/10.1007/BF01850970