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High frequency of autonomous T-cell proliferation compatible with T-cell large granular lymphocytic leukemia in patients with cytopenia of unknown etiology

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Abstract

Large granular lymphocytic leukemia/lymphoproliferative disorder (LGL-L/LPD) is a heterogeneous neoplastic disease of large granular lymphocytes and is a well-known cause of cytopenias. We aimed to reveal the incidence of LGL-L/LPD in patients with cytopenia(s) of unknown etiology (CUE). Twenty-eight patients with CUE were investigated for LGL-L/LPD. T-cell LGL leukemia (LGL-L) was diagnosed in 12 (42.9 %) patients. The frequencies of LGL-L in patients who had anemia, neutropenia, and thrombocytopenia were 9/14 (64.2 %), 11/23 (47.8 %), and 3/10 (30 %), respectively. Seventeen of the 28 patients met the criteria of idiopathic cytopenia of undetermined significance (ICUS), and LGL-L was found in six (35.3 %) of them. We conclude that LGL-L is a rather common disease in patients with CUE and ICUS. It should be considered in this patient group and investigated thoroughly.

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The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Hematology, Faculty of Medicine, Hacettepe University, 06100, Sihhiye, Ankara, Turkey

    Ozlen Bektas, Seda Muruvvet Aydin, Eylem Eliacik, Burak Uz, Ayse Işık, Ibrahim Celalettin Haznedaroğlu, Hakan Goker, Nilgun Sayinalp, Salih Aksu, Halûk Demiroglu, Osman Ilhami Ozcebe & Yahya Buyukasik

  2. Department of Pathology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

    Aysegul Uner

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  1. Ozlen Bektas
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  2. Aysegul Uner
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  3. Seda Muruvvet Aydin
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  13. Yahya Buyukasik
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Correspondence to Yahya Buyukasik.

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Bektas, O., Uner, A., Aydin, S.M. et al. High frequency of autonomous T-cell proliferation compatible with T-cell large granular lymphocytic leukemia in patients with cytopenia of unknown etiology. Int J Hematol 102, 211–217 (2015). https://doi.org/10.1007/s12185-015-1816-y

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  • DOI: https://doi.org/10.1007/s12185-015-1816-y

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