Abstract
Using three sets of recombinant inbred strains (BXD, BXH, and BXJ), we found the locus controlling an antigenic substance (Sas}-1) in murine serum to be closely linked to the Chromosome-1 marker,Dip-1. This linkage was confirmed by an analysis of backcross linkage. The BXD and backcross data suggest that the gene order isId-1-Dip-1-Sas-1-Mls. Data from the three sets of RI strains and the 32 backcross mice lead to the estimate that the recombination frequency betweenDip-1 andSas-1 is 0.030 ±0.015.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Chapman, V.M., Ruddle, F.H., and Roderick, T.H.: Linkage of isozyme loci in the mouse; phosphoglucomutase-2 (Pgm-2), mitochondrial NADP malate dehydrogenase (Mod-2), and dipeptidase-1 (Dip-1).Biochem. Genet. 5:101–111, 1971
DaSilva, P.F., Hoecker, G.F., Day, N.K., Vienne, K., and Rubinstein, P.: Murine complement components: Genetic variation and linkage to H-2.Proc. Natl. Acad. Sci. U.S.A. 75:963–965, 1978
Dickler, H.G., Ahmed, A., and Sachs, D.H.: B-lymphocyte Fc receptor-associated non-H-2 antigens are determined by a single polymorphic locus which is linked to the Mls locus.J. Exp. Med. 146:1678–1692, 1977
Festenstein, H., Bishop, C., and Taylor, B.A.: Location ofMls locus on mouse chromosome 1.Immunogenetics 5:357–361, 1977
Haldane, J.B.S. and Waddington, C.H.: Inbreeding and linkage.Genetics 16:357–374, 1931
Henderson, N.S.: Isozymes and genetic control of NADP-malate dehydrogenase in mice.Arch. Biochem. Biophys. 117:28–33, 1966
Melvold, R.W.: Spontaneous somatic reversion in mice: Effects of parental genotype on stability at theplocas.Mutat.Res. 72:171–174, 1971
Naylor, D.H. and Cinader, B.: Inheritance, hormonal regulation and properties polymorphic murine antigens Mud-1 and Mud-2.Int. Arch. Allergy 39:511–539, 1975
Taylor, B.A., Bailey, D.W., Cherry, M., Riblet, R., and Weigert, M.: Genes for immunoglobulin heavy chain and serum prealbumin protein are linked in mouse.Nature 256:644, 1975
Taylor, B.A., Bedigian, H.G., and Meier, H.: Genetic studies of the Fv-1 locus of mice: Linkage with Gpd-1 in recombinant inbred lines.J. Virol. 23:106–109, 1977
Taylor, B.A. and Meier, H.: Mapping the adrenal lipid depletion gene of the AKR/J mouse strain.Genet. Res. 26:307–312, 1976
Taylor, B.A. and Shen, F.-W.: Location of Lyb-2 on mouse chromosome4: Evidence from recombinant inbred strains.Immunogenetics 4:597–599, 1977
Watson, J., Riblet, R., and Taylor, B.A.: The response of recombinant inbred strains of mice to bacterial lipopolysaccharides.J. Immunol. 118:2088–2093, 1977
Wortis, H.H.: A gene locus concerned with an antigenic serum substance inMus musculus.Genetics 52:267–273, 1965
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Rosenstreich, D.L., Groves, M.G., Hoffman, H.A. et al. Location of theSas-1 locus on mouse chromosome 1. Immunogenetics 7, 313–320 (1978). https://doi.org/10.1007/BF01844021
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01844021