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Immunoglobulin isoantigens (allotypes) in the mouse

V. Characterization of IgM allotypes

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Abstract

Murine antisera raised against allogeneic lymphoid cells often contain antibodies to IgM allotypes. Rarely, allotypic antibodies to IgM have been found after immunization withB. pertussis anti-B. pertussis conjugates. Using both types of antibodies, we have defined a new constant-region locus for both secreted and membrane-bound μ chains. This locus,Ig-6, is closely linked to the previously described H-chain constant-region loci (Ig-1 throughIg-5) and is subject to allelic exclusion. We have identified three alleles and four antigenic specificities ofIg-6.

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Authors and Affiliations

  1. Department of Genetics, Stanford University School of Medicine, 94305, Stanford, California

    Samuel J. Black, Leonard A. Herzenberg, Michael R. Loken, Barbara A. Osborne & Wessel van der Loo

  2. The Walter and Eliza Hall Institute of Medical Research, c/o Royal Melbourne Hospital Post Office, 3050, Victoria, Australia

    James W. Goding, George A. Gutman & Noel L. Warner

Authors
  1. Samuel J. Black
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  2. James W. Goding
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  3. George A. Gutman
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  4. Leonard A. Herzenberg
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  5. Michael R. Loken
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  6. Barbara A. Osborne
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  7. Wessel van der Loo
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  8. Noel L. Warner
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Black, S.J., Goding, J.W., Gutman, G.A. et al. Immunoglobulin isoantigens (allotypes) in the mouse. Immunogenetics 7, 213–230 (1978). https://doi.org/10.1007/BF01844009

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  • DOI: https://doi.org/10.1007/BF01844009

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