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Effect of dipyridamole on invasion of five types of malignant cells in organ culture

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Abstract

Dipyridamole (DPD) has been shown to inhibit the motility of cells in culture. We have tested the effect of DPD on the invasion in confronting organ culture of the following malignant cell lines: mouse MO4 cells; rat NBT II bladder tumor cells; human SA4 glioblastoma cells; mouse LLC H61 lung carcinoma cells; and mouse F87 C1.6T2 melanoma × lymphocyte hybrid cells. At concentrations of 20μg/ml or higher, DPD inhibited the invasion of all cell types into embryonic chick heart. In serum-free culture medium the anti-invasive concentration of DPD was about ten times lower. Anti-invasive concentrations of DPD also inhibited proliferation of the malignant cells. Both inhibition of invasion and of proliferation were reversible.

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Authors and Affiliations

  1. Laboratory of Experimental Cancerology, Department of Radiotherapy and Nuclear Medicine, University Hospital, De Pintelaan 185, B-9000, Gent, Belgium

    N. Van Larebeke, C. Dragonetti & M. Mareel

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  1. N. Van Larebeke
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  2. C. Dragonetti
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  3. M. Mareel
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Van Larebeke, N., Dragonetti, C. & Mareel, M. Effect of dipyridamole on invasion of five types of malignant cells in organ culture. Clin Exp Metast 7, 645–657 (1989). https://doi.org/10.1007/BF01753675

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  • DOI: https://doi.org/10.1007/BF01753675

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