Abstract
The effect of synthetic nucleoside derivatives on the growth and survival of cultured human ovarian cancer cells (line SKOV-3) and normal human lung fibroblasts has been investigated. The dialdehyde derivatives of uridine, 1-β-D-erythrofuranosyl uracil and 3′-O-β-D-ribofuranosyl-2′-deoxythymidine exhibited a marked toxic effect on SKOV-3 cells, while their unoxidized analogues did not exhibit such action. Cultured human fibroblasts were less susceptible to the damaging effect of the dialdehyde nucleosides. The dialdehyde derivative of 1-β-D-erythrofuranosyl uracil demonstrated the highest difference in its cytotoxic effect on these cultures: 50% or higher suppression of SKOV-3 cells growth was achieved at the concentrations of this compound ten times lower than in the case of normal fibroblasts.
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Liekens, S., Bronckaers, A., and Balzarini, J., Lancet Oncol., 2009, vol. 10, no. 6, pp. 628–635.
Koczor, C.A., Torres, R.A., and Lewis, W., Expert Opin. Drug Metab. Toxicol., 2012, vol. 8, no. 6, pp. 665–676.
Galmarini, C.M., Mackey, J.R., and Dumonte, C., Lancet Oncol., 2002, vol. 3, no. 7, pp. 415–424.
Faderl, S., Gandhi, V., and Kantarjian, H.M., Curr. Opin. Hematol., 2008, vol. 15, no. 2, pp. 101–107.
Parker, W.B., Chem. Rev., 2009, vol. 109, no. 7, pp. 2880–2893.
Mikhailov, S.N., De Clerq, E., Herdewijn, P., Nucleosides Nucleotides Nucleic Acids, 1996, vol. 15, nos. 7–8, pp. 1323–1334.
Ermolinsky, B.S. and Mikhailov, S.N., Rus. J. Bioorg. Chem., 2000, vol. 26, no. 7, pp. 429–449.
Efimtseva, E.V., Kulikova, I.V., and Mikhailov, S.N., Current Organic Chem., 2007, vol. 11, no. 4, pp. 337–354.
Efimtseva, E.V., Kulikova, I.V., and Mikhailov, S.N., Mol. Biol. (Mosk.), 2009, vol. 43, no. 2, pp. 301–312.
Cory, J.G. and Mansell, M.M., Cancer Res., 1975, vol. 35, no. 2, pp. 390–396.
Ohmstede, C.A. and Cory, J.G., Biochem. Pharmacol., 1985, vol. 34, no. 10, pp. 1717–1724.
Efremova, A.S., Zakharenko, A.L., Shram, S.I., Kulikova, I.V., Drenichev, M.S., Sukhanova, M.V., Khodyreva, S.N., Myasoedov, N.F., Lavrik, O.I., and Mikhailov, S.N., Nucleosides Nucleotides Nucleic Acids, 2013, vol. 32, no. 9, pp. 510–528.
Jordheim, L.P., Durantel, D., Zoulim, F., and Dumontet, C., Nat. Rev. Drug Discov., 2013, vol. 12, no. 6, pp. 447–464.
Muggia, F., Diaz, I., and Peters, G.J., Expert Opin. Investig. Drugs, 2012, vol. 21, no. 4, pp. 403–408.
Sheid, B., Saggar, M., Gaetjens, E., and Lerner, L.M., Cancer Chemother. Pharmacol., 1991, vol. 28, no. 5, pp. 339–343.
Plagemann, P.G., Graff, J.C., and Behrens, M., Cancer Res., 1977, vol. 37, no. 7, Pt 1, pp. 2188–2195.
Lee, M.H., Lazo, J.S., Li, C.D., Hadfield, A.F., Maniglia, C.A., and Sartorelli, A.C., Chem. Biol. Interact., 1982, vol. 41, no. 2, pp. 141–153.
Mirkin, B.L., O’Dea, R.F., and Hogenkamp, H.P., Cancer Res., 1987, vol. 47, no. 14, pp. 3650–3655.
Sato, T., Yagori, A., and Niwa, M., Pharmacol. Toxicol., 1987, vol. 61, no. 5, pp. 313–315.
Holz, O., Zühlke, I., Jaksztat, E., Müller, K.C., Welker, L., Nakashima, M., Diemel, K.D., Branscheid, D., Magnussen, H., and Jörres, R.A., Eur. Respir. J., 2004, vol. 24, no. 4, pp. 575–579.
Buick, R.N., Pullano, R., and Trent, J.M., Cancer Res., 1985, vol. 45, no. 8, pp. 3668–3676.
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Original Russian Text © A.S. Efremova, S.I. Shram, M.S. Drenichev, G.A. Posypanova, N.F. Myasoedov, S.N. Mikhailov, 2014, published in Biomeditsinskaya Khimiya.
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Efremova, A.S., Shram, S.I., Drenichev, M.S. et al. The selective toxic effect of dialdehyde derivatives of pyrimidine nucleosides on human ovarian cancer cells. Biochem. Moscow Suppl. Ser. B 8, 318–322 (2014). https://doi.org/10.1134/S1990750814040027
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DOI: https://doi.org/10.1134/S1990750814040027