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The effect of phagocytosis ofCandida albicans blastospores on alkaline phosphatase levels in rat polymorphonuclear leucocytes

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Summary

The phagocytic function of young polymorphonuclear leucocytes with high levels of leucocyte alkaline phosphatase, which are present in the peripheral blood during an inflammatory response, was compared with that of normal polymorphonuclear leucocytes.Candida albicans blastospores were used as phagocytic targets. The phagocytic index of polymorphonuclear leucocytes with low levels of leucocyte alkaline phosphatase was higher than that of cells with high levels of enzyme.

Monitoring of leucocyte alkaline phosphatase levels with increasing times of incubation of leucocytes with the blastospores showed a progressive decline in the level of the enzyme. Thus loss of the enzyme is linked to the phagocytic function, although the mechanism of this dynamic process is unclear.

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Authors and Affiliations

  1. Department of Oral Pathology, London Hospital Medical College, Turner Street, E1 2AD, London, UK

    W. H. M. Lu & D. M. Williams

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  1. W. H. M. Lu
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  2. D. M. Williams
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Lu, W.H.M., Williams, D.M. The effect of phagocytosis ofCandida albicans blastospores on alkaline phosphatase levels in rat polymorphonuclear leucocytes. Histochem J 19, 333–336 (1987). https://doi.org/10.1007/BF01680449

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  • DOI: https://doi.org/10.1007/BF01680449

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