Abstract
Further serological analyses of the tissue and strain distributions for the Qa-2 antigens indicate that this locus should be subdivided into two loci,Qa-2 andQa-3. TheQa-2 locus determines a lymphocyte alloantigen which is present predominantly on Thy-1+ cells. The lymphocyte alloantigen determined by theQa-3 locus is more limited in its tissue distribution and appears only on lymph node and splenic lymphocytes. Testing of anti-H-2.28 sera has revealed that at least one anti-H-2.28 serum contains anti-Qa-2 and/or anti-Qa-3 activity.
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Boyse, E.A., Old, L.J., and Chouroulinkov, I.: Cytotoxicity test for demonstration of mouse antibody.Methods Med. Res. 10:39–47, 1964
Boyse, E.A., Old, L.J., and Stoekert, E.: The TL (thymus leukemia) antigen: a review.In P. Grabar and P.A. Miescher (eds.): Immunopathology:Fourth International Symposium, Monte Carlo, pp. 23–40. Schwabe and Co., Basel, 1965
Boyse, E.A., Hubbard, L., Stoekert, E., and Lamm, M.E.: Improved complementation in the cytotoxic test.Transplantation 10:446–449, 1970
Demant, P., Snell, G.D., Hess, M., Lemonnier, F., Neauport-Sautes, C., and Kourilsky, F.M.: Separate and polymorphic loci controlling two types of polypeptide chains bearing the H-2 private and public specificities.J. Immunogenetics 2:263–271, 1975
Flaherty, L.: TheTla region of the mouse: identification of a new serologically defined locus,Qa-2.Immunogenetics 3:533–539, 1976
Flaherty, L. and Wachtel, S.S.: H(Tla) system: identification of two new loci,H-31 andH-32, and alleles.Immunogenetics 2:81–85, 1975
Gorer, P.A., and O'Gorman, P.: The cytotoxic activity of isoantibodies in mice.Transplant. Bull. 3:142–143, 1956
Hansen, T.H., Cullen, S.E., Melvold, R., Kohn, H., Flaherty, L., and Sachs, D.H.: Mutation in a new H-2-associated histocompatibility gene closely linked toH-2D.J. Exp. Med. 145:1550–1558, 1977
Julius, M.E., Simpson, E., and Herzenberg, L.A.: A rapid method for the isolation of functional thymus-derived lymphocytes.Eur. J. Immunol. 3:645–649, 1973
Lemonnier, F., Neauport-Sautes, C., Kourilsky, F.M., and Démant, P.: Relationship between private and publicH-2 specificities on the cell surface.Immunogenetics 2:517–529, 1975
Morello, D., Neauport-Sautes, C., and Démant, P.: Topographical relationships among H-2 specificities controlled by theD region.Immunogenetics 4:349–364, 1977
Shen, F-W., Boyse, E.A., and Cantor, H.: Preparation and use of Ly antisera.Immunogenetics 2:591–595, 1975
Stanton, T. and Boyse, E.A.: A new serologically defined locus,Qa-1, in theTla region of the mouse.Immunogenetics 3:525–531, 1976
Young, C.R., Deacon, N.J., Ebringer, A., and Davies, D.A.L.: Genetic control of the immune response to ferritin in mice.J. Immunogenetics 3:199–205, 1976
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Flaherty, L., Zimmerman, D. & Hansen, T.H. Further serological analysis of the Qa antigens: Analysis of an anti-H-2.28 serum. Immunogenetics 6, 245–251 (1978). https://doi.org/10.1007/BF01563914
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DOI: https://doi.org/10.1007/BF01563914