Summary
The relationship between the plasma concentration of high-density-lipoprotein(HDL)-cholesterol, very-low-density-lipoprotein(VLDL)-triglycerides, and low-density-lipoprotein(LDL)-cholesterol and the fractional removal rate (K2) of an intravenously administered fat emulsion (Intralipid®) was investigated in 13 normo- and 34 hypertriglyceridaemics. A highly significant correlation (p<0,001) between the plasma concentration of HDL-cholesterol and the fractional removal rate of exogenous triglycerides was found for both groups. No significant relationship existed between the concentration of VLDL-triglycerides and of LDL-cholesterol and the removal rate of exogenous triglycerides.
These observations suggest a major role of HDL in the removal of plasma triglycerides.
Zusammenfassung
Bei 13 Normo- und 34 Hypertriglyzeridämikern wurden die Beziehungen zwischen den Plasmakonzentrationen von High-density-lipoprotein(HDL)-Cholesterin, Very-low-density(VLDL)-Triglyzeriden, Low-density-Lipoprotein(LDL)-Cholesterin und der fraktionellen Verschwinderate (K2) einer intravenös applizierten Fettemulsion (Intralipid®) untersucht. Für die Gruppe der Normal-personen und für die Gruppe der Hypertriglyzeridämiker bestand eine jeweils hochsignifikante Korrelation (p<0,001) zwischen der Plasmakonzentration von HDL-Cholesterin und dem K2-Wert. Zwischen der Plasmakonzentration der VLDL-Triglyzeride bzw. des LDL-Cholesterins und dem K2-Wert ergaben sich für beide Gruppen keine statistisch gesicherten Beziehungen.
Auf Grund dieser Befunde dürften die HDL wesentlich am Abtrasport der Plasmatriglyzeride beteiligt sein.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literatur
Albrink, M.J., Meigs, J.W., Man, E.B.: Serum lipids, hypertension and coronary artery disease. Amer. J. Med.31, 4 (1961)
Barr, D.P., Russ, E.M., Eder, H.A.: Protein-lipid relationship in human plasma. Amer. J. Med.11, 480 (1951)
Beaumont, J.L., Carlson, L.A., Cooper, G.R., Fejfar, Z., Fredrickson, D.S., Strasser, T.: Classification of hyperlipidaemias. Bull. Wld. Hlth. Org.43, 891 (1970)
Boberg, J., Carlson, L.A., Hallberg, D.: Application of a new intravenous fat tolerance test in the study hypertriglyceridaemia in man. J. Atheroscler. Res.9, 159 (1969)
Carlson, L.A., Böttiger, L.E.: Ischemic heart disease in relation to fasting values of plasma triglycerides and cholesterol. Lancet1, 865 (1972)
Carlson, L.A., Ericsson, M.: Quantitative and qualitative serum lipoprotein analysis. 2. Studies in male survivors of myocardial infarction. Atherosclerosis21, 435 (1975)
Carlson, L.A., Rössner, S.: A methodological study of an intravenous fat tolerance test with intralipid emulsion. Scand. J. clin. Lab. Invest.29, 243 (1972)
Documenta Geigy, Wissenschaftliche Tabellen 1968
Fredrickson, D.S., Levy, R.I., Lees, R.S.: Fat transport in lipoproteins — An integrated approach to mechanisms and disorders. New Engl. J. Med.276, 148 (1967)
Gofman, J.W., Young, W., Tandy, R.: Ischemic heart disease, atherosclerosis and longevity. Circulation34, 679 (1966)
Gordon, T., Castelli, W.P., Hjortland, M.C., Kannel, W.B., Dawber, T.R.: High density lipoprotein as a protective factor against coronary heart disease. Amer. J. Med.62, 707 (1977)
Kannel, W.B., Castelli, W.P., Gordon, T., Mcnamara, P.M.: Serum cholesterol, lipoproteins, and risk of coronary heart disease. The Framingham Study. Ann. Intern. Med.74, 1 (1971)
Kessler, G., Lederer, H.: Fluorimetric measurement of triglyceride. In: Automation in Analytical Chemistry, ed.: L.T. Skeggs, p. 341. New York: Mediac. Inc. 1965
Liebermann, N.S., Buchard, H., In: Technicon Symposia, ed.: R. Levine, S. Morgenstern and D. Vlastelica, p. 25. New York: Mediac Inc. 1967
Noble, R.P.: Electrophoretic separation of plasma lipoproteins in agarosegel. J. Lip. Res.9, 693 (1968)
Rössner, S., Boberg, J., Carlson, L.A., Freyschuss, U., Lassers, B.W.: Comparison between fractional turnover rate of endogenous plasma triglycerides and of intralipid® (intravenous fat tolerance test) in man. Europ. J. clin. Invest.4, 109 (1974)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Lisch, H.J., Sailer, S. & Braunsteiner, H. Beziehung zwischen der Plasmakonzentration der Lipoproteide hoher Dichte (HDL) und der intravenösen Fettoleranz bei Normo- und Hypertriglyzeridämikern. Klin Wochenschr 56, 797–800 (1978). https://doi.org/10.1007/BF01489712
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01489712