Skip to main content
SpringerLink
Log in

Scrapie in the rat: an electron-microscopic study

II. Glial inclusions

  • Original Investigations
  • Published:
Acta Neuropathologica Aims and scope Submit manuscript

    We’re sorry, something doesn't seem to be working properly.

    Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.

Summary

Microglial activation accompanies astroglial proliferation in rat scrapie. Enlarged microglial cells show a variety of bizarre inclusions within their cytoplasm, some taking the form of a lyre, others being rod like and packed so as to simulate branching; others again are quadrilateral. These are made up of large numbers of clearly packed parallel lamellae about 60 Å wide separated by intervals of about 120 Å.

Accumulations of closely packed tubules occur within the larger myelinated nerve fibres which traverse the granular layer of the cerebellum.

Zusammenfassung

Beim Scrapie der Ratte wird die Astrogliaproliferation von einer Aktivierung der Mikroglia begleitet. Vergrößerte Mikrogliazellen zeigen eine Art bizarrer intracytoplasmatischer Einschlüsse. Einige zeigen die Form einer Lyra, andere sind stabförmig und in der Weise gepackt, daß sie eine Verzweigung vortäuschen, während andere wieder rechteckig erscheinen. Diese werden von einer großen Zahl dicht gepackter paralleler Lanmellen von rund 60 Å Dicke gebildet, die durch Zwischenräume von rund 120 Å getrennt sind. Anhäufungen von dicht gepackten Tubuli treten innerhalb der größeren bemarkten Nervenfasern auf, welche die Körnerschicht des Kleinhirns durchziehen.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Beck, Elizabeth, P. M. Daniel, andH. B. Parry: Degeneration of the cerebellar and hypothalamo-neurohypophyseal systems in sheep with scrapie; and its relationship to human system degenerations. Brain87, 153–176 (1964).

    PubMed  Google Scholar 

  • Blinzinger, K., andH. Hager: Elektromikroskopische Untersuchungen über die Feinstruktur ruhender und progressiver Mikrogliazellen im Säugetiergehirn. Beitr. path. Anat.127, 173–192 (1962).

    Google Scholar 

  • Duncan, D., andV. Williams: On the occurrence of precise order in axoplasm. Tex. Rep. Biol. Med.20, 503–505 (1962).

    PubMed  Google Scholar 

  • Field, E. J.: Microglial reaction in rabies infection of the mouse and rabbit. J. comp. Path.64, 213–216 (1954).

    PubMed  Google Scholar 

  • —: Histogenesis of compound granular corpuscles in the mouse brain after trauma and a note on the influence of cortisone. J. Neuropath. exp. Neurol.16, 48–55 (1957).

    PubMed  Google Scholar 

  • —, andC. S. Raine: An electron microscopic study of scrapie in the mouse. Acta neuropath. (Berl.)4, 200–211 (1964).

    Google Scholar 

  • —— andGreta Joyce: An electron microscopic study of scrapie in the rat. I. The occurrence of amyloid bodies and deposits. Acta neuropath. (Berl.)8, 47–56 (1967).

    Google Scholar 

  • Hadlow, W. J.: The pathology of experimental scrapie in the dairy goat. Res. Vet. Sci.2, 289–314 (1961).

    Google Scholar 

  • Hirano, A.: Pathology of amyotrophic lateral sclerosis. In: Slow, latent and temperate virus infections. Ed.D. C. Gajdusek, C. J. Gibbs, jr., andM. Alpers. N.I.N.D.B. Monograph No. 2. (1965).

  • Morales, R., andD. Duncan: Multilaminated bodies and other unusual configurations of endoplasmic reticulum in the cerebellum of the cat. An electron microscopic study. J. Ultrastruct. Res.15, 480–489 (1966).

    PubMed  Google Scholar 

  • Raine, C. S., andE. J. Field: Orientated tubules in axoplasm of cerebellar myelinated nerve fibres in the rat. Acta Neuropath. (in the press 1967).

  • Schultz, R. L., E. A. Maynard, andD. C. Pease: Electron microscopy of neurons and neuroglia of cerebral cortex and corpus callosum. Amer. J. Anat.100, 369–407 (1957)

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Medical Research Council Demyelinating Diseases Research Unit, Royal Victoria Infirmary and University of Newcastle upon Tyne, 13 Framlington Place, Newcastle upon Tyne 2, England

    E. J. Field M.D., M.S., Ph.D., M.R.C.P., C. S. Raine B.Sc. & Greta Joyce A.M.I.L.T.

Authors
  1. E. J. Field M.D., M.S., Ph.D., M.R.C.P.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. S. Raine B.Sc.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Greta Joyce A.M.I.L.T.
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

We should like to thank Mr.I. H. Pattison of the Institute for Research on Animal Diseases, Compton, Nr. Newbury, Berkshire, for providing the original scrapie rat material, and also MissChristine Colligan for technical assistance.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Field, E.J., Raine, C.S. & Joyce, G. Scrapie in the rat: an electron-microscopic study. Acta Neuropathol 9, 305–315 (1967). https://doi.org/10.1007/BF01371190

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01371190

Keywords

Search

Navigation