Summary
Acute and convalescent sera from 77 patients with serologically confirmed influenza, measles and adenovirus infections and from 36 healthy controls were tested for the level of antibodies to Epstein-Barr (EB) virus. In the three groups of patients significantly higher titers of antibodies to EB viral capsid antigen (VCA) were found as compared to the controls. In 19 patients twofold or higher rise in antibody titers between the first and second blood sample was demonstrated.
It is suggested that in patients with influenza, measles or adenovirus infections, involvement of lymphocytes leads to reactivation of EB virus and antibody formation is stimulated.
Similar content being viewed by others
References
Chiba, Y., Dzierba, J. L., Morag, A., Ogra, P. L.: Cell-mediated immune response to mumps virus infection in man. J. Immunol.116, 12–15 (1976).
Feorino, P. M., Humphrey, D., Hochberg, F., Chilicote, R.: Mononucleosis associated subacute sclerosing panencephalitis. LancetII, 530–532 (1975).
Ganguly, R., Cusumano, C. L., Waldman, R. H.: Suppression of cell-mediated immunity after infection with attenuated rubella virus. Infect. Immun.13, 464–469 (1976).
Gerber, P., Nonoyama, M., Lucas, S., Perlin, E., Goldstein, L. I.: Oral excretion of Epstein-Barr virus by healthy subjects and patients with infectious mononucleosis. LancetII, 988–989 (1972).
Gerson, K. L., Haslam, R. H. A.: Subtle immunologic abnormalities in four boys with subacute sclerosing panencephalitis. J. Amer. med. Ass.216, 1201–1202 (1971).
Gotlieb-Stematsky, T., Rannon, L., Vonsover, A.: Antibodies to Epstein-Barr virus in subacute sclerosing panencephalitis patients. Europ. Neurol.13, 418–421 (1975).
Gotlieb-Stematsky, T., Ramot, B., Vonsover, A., Aghai, H., Kende, G., Ninio, M., Modan, M.: Antibodies to Epstein-Barr viral capsid and early antigen associated with Burkitt's lymphoma and lymphoblastic lymphosarcoma in Israel. J. Nat. Cancer Inst.56, 721–723 (1976).
Gotlieb-Stematsky, T., Vonsover, A., Ramot, B., Zaizov, R., Nordan, U., Aghai, E., Kende, G., Modan, M.: Antibodies to Epstein-Barr virus in patients with Hodgkin's disease and leukemia. Cancer36, 1640–1645 (1975).
Gresser, I., Chany, C.: Isolation of measles virus from washed leucocytic fraction of blood. Proc. Soc. exp. Biol. Med.113, 695–698 (1973).
Henle, G., Henle, W.: Immunofluorescence in cells derived from Burkitt's lymphoma. J. Bacteriol.91, 1248–1256 (1966).
Horta-Barbosa, L., Fucillo, D. A., Sever, J. L., Zeman, W.: Subacute sclerosing panencephalitis: Isolation of measles virus from a brain biopsy. Nature221, 974 (1969).
Joncas, J. H.: Clinical significance of the EB herpesvirus infection in man. In:Melnick, J. L. (ed.), Progr. med. Virol.14, 200–240. Basel: Karger 1972.
Joncas, J., Geoffroy, R., McLaughlin, B., Albert, G., Lapointe, N., David, P., Lafontaine, R., Granger-Julien, M.: Subacute sclerosing panencephalitis elevated Epstein-Barr virus antibody titers and failure of amantadine therapy. J. neurol. Sci.21, 381–390 (1974).
Kantzler, G. B., Lauteria, S. F., Cusumano, C. L., Lee, J. D., Ganguly, R., Waldman, R. H.: Immunosuppression during influenza virus infection. Infect. Immun.10, 996–1002 (1974).
Niederman, J. C., Evans, A. S., Subrahmanyan, L., McCollum, R. W.: Prevalence, incidence and persistence of EB virus antibody in young adults. N. Eng. J. Med.282, 361–365 (1970).
Norrby, E.: Hemagglutination by measles virus. A simple procedure for production of high potency antigen for hemagglutination inhibition (HI) test. Proc. Soc. exp. Biol. Med.111, 814–818 (1962).
Osunkoya, B. O., Cooke, A. R., Ayeni, O., Adejumo, T. A.: Studies on leukocyte cultures in measles. 1. Lymphocyte transformation and giant cell formation in leukocyte culture from clinical cases of measles. Arch. ges. Virusforsch.44, 313–322 (1974).
Reed, W. P., Olds, J. W., Kisch, A. L.: Decreased skin-test reactivity associated with influenza. J. inf. Dis.125, 398–402 (1972).
Rosen, L.: Haemagglutination and haemagglutination inhibition with measles virus. Virology13, 139–141 (1961).
Scheinberg, M. A., Blacklow, N. R., Goldstein, A. L., Parrino, T. A., Rose, F. B., Cathart, E. S.: Influenza: response of T-cell lymphopenia to thymosin. N. Engl. J. Med.294, 1208–1211 (1976).
Sohier, R., Chardonnet, Y., Prunieras, M.: Adenoviruses, status of current knowledge. Progr. med. Virol.7, 253–325 (1965).
de Thé, G.: Virology and immunology of nasopharyngeal carcinoma: Present situation and outlook—a review. In:Biggs, P. M., de The, G., Payne, L. N. (eds.), Oncogenesis and Herpesviruses, 275–284. Lyon: IARC 1972.
Westwater, J. S.: Tuberculin allergy in acute infectious diseases: a study of the intracutaneous test. Q. J. Med.4, 203–225 (1935).
White, R. G., Boyd, J. F.: The effect of measles on the thymus and other lymphoid tissues. Clin. exp. Immunol.13, 343–357 (1973).
Zur Hausen, H., Diehl, V., Wolf, H., Schulte-Holthausen, H., Schneider, U.: Occurrence of Epstein-Barr virus genomes in human lymphoblastoid cell lines. Nature New Biol.237, 189–190 (1972).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Gotlieb-Stematsky, T., Rannon, L., Vonsover, A. et al. Stimulation of antibodies to Epstein-Barr virus (EBV) in acute viral infections. Archives of Virology 57, 199–204 (1978). https://doi.org/10.1007/BF01315084
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01315084