Skip to main content
SpringerLink
Log in

Comparative effects of bombesin and porcine gastrin-releasing peptide in the dog

  • Original Articles
  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

Abstract

Bombesin and porcine gastrin-releasing peptide (GRP) share a common C-terminal decapeptide fragment and are known to have similar bioactivity. The potencies of parenterally administered GRP and bombesin have been compared in their effects on gastric acid output, serum gastrin, and serum pancreatic polypeptide. In the dose range 0–720 pmol/kg/hr, infusions of both peptides resulted in dose-related increases of gastric acid output and corresponding elevations of serum gastrin and pancreatic polypeptide. At the dose of 1440 pmol/kg/hr, both bombesin and GRP resulted in a decrease in gastric acid output and serum gastrin. The mechanism of this inhibition is unknown. No significant difference in potency between the two peptides in changing gastric acid output, serum gastrin, and pancreatic polypeptide was observed. The demonstration of equimolar potency of porcine GRP and bombesin support the concept that GRP is mammalian bombesin.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Walsh JH, Holmquist AL: Radioimmunoassay of bombesin peptides identification of bombesin like immunoreactivity in vertebrate gut extracts. Gastroenterology 70:948, 1976 (abstract)

    Google Scholar 

  2. Polak JM, Bloom SR, Hobbs S, et al: Distribution of a bombesin-like peptide in human gastrointestinal tract. Lancet 1:1109–1110, 1976

    Google Scholar 

  3. McDonald TJ, Nilsson G, Vagne M, et al: A gastrin releasing peptide from the porcine nonantral gastric tissue. Gut 19:767–774, 1978

    Google Scholar 

  4. Rivier JE, Brown MR: Bombesin, bombesin analogues and related peptides. Effects on the thermoregulation. Biochemistry 17:1766–1771, 1978

    Google Scholar 

  5. McDonald TJ, Jornvall H, Nilsson G, et al: Characterization of a gastrin releasing peptide from porcine nonantral gastric tissue. Biochem Biophys Res Commun 90:227–233, 1979

    Google Scholar 

  6. McDonald TJ, Jornvall H, Ghatei M, et al: Characterization of an avian gastric (proventricular) peptide having sequence homology with the porcine gastrin-releasing peptide and the amphibian peptides bombesin and alytensin. FEBS Lett 122:45–48, 1980

    Google Scholar 

  7. Brown M, Marki W, Rivier J: Is gastrin-releasing peptide mammalian bombesin? Life Sci 27:125–128, 1980

    Google Scholar 

  8. Tache Y, Marki W, Rivier J, et al: Central nervous system inhibition of gastric secretion in the rat by gastrin releasing peptide, a mammalian bombesin. Gastroenterology 81:298–301, 1981

    Google Scholar 

  9. Dubrasquet M, Roze C, Ling N, et al: Inhibition of gastric and pancreatic secretions by cerebroventricular injections of gastrin-releasing peptide and bombesin in rats. Regul Peptides 3:105–112, 1982

    Google Scholar 

  10. Reeve JR, Walsh JH, Chew P, et al: Amino acid sequences of three bombesin-like peptides from canine intestine extracts. J Biol Chem 258:5582–5588, 1983

    Google Scholar 

  11. Jones RS, Yee TK, Michielsen CE: A modified Thomas cannula for gastric and intestinal fistulas. J Appl Physiol 30:427–428, 1971

    Google Scholar 

  12. Hansky J, Soveny C: Radioimmunoassay of gastrin.In Handbook of Radioimmunoassay. GE Abraham (ed). New York, Marcel Dekker, 1977, pp 459–482

    Google Scholar 

  13. Stern AI, Hansky J, Korman MG, et al: Pancreatic polypeptide release following surgery for duodenal ulcer disease. Dig Dis Sci 25:485–488, 1980

    Google Scholar 

  14. Soveny C, Hansky J: Bombesin-like immunoreactivity in rat brain and gastrointestinal tract: influence of diet and starvation. Regul Peptides 3:325–331, 1982

    Google Scholar 

  15. McDonald TJ, Ghatei MA, Bloom SR, et al: Dose-response comparisons of canine plasma gastroenteropancreatic hormone responses to bombesin and the porcine gastrin-releasing peptide (GRP). Regul Peptides 5:125–137, 1983

    Google Scholar 

  16. Rokaeus A, Yanaihara N, McDonald TJ: Increased concentration of neurotensin-like immunoreactivity in rat plasma after administration of bombesin and bombesin-related peptides (porcine and chicken gastrin-releasing peptides). Acta Physiol Scand 114:605–619, 1982

    Google Scholar 

  17. Ghatei MA, Jung RT, Stevenson JC, et al: Bombesin: Action of gut hormones and calcium in man. J Clin Endocrinol Metab 54:980–985, 1982

    Google Scholar 

  18. Erspamer V, Falconeri Erspamer G, Melchiorri P, et al: Occurrence and polymorphism of bombesin-like peptides in the gastrointestinal tract of birds and mammals. Gut 20:1047–1056, 1979

    Google Scholar 

  19. Dockray GJ, Vaillant C, Walsh JH: The neuronal origin of bombesin-like immunoreactivity in the rat gastrointestinal tract. Neuroscience 4:1561–1568, 1979

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Medicine and Surgery, Prince Henry's Hospital, Monash University, St. Kilda Road, 3004, Melbourne, Victoria, Australia

    J. R. Lambert MB, BS, FRCP(C),  J. Hansky MB, BS, FRACP, C. Soveny B APPL SC & P. Hunt MS, FRCS

Authors
  1. J. R. Lambert MB, BS, FRCP(C)
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. Hansky MB, BS, FRACP
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. C. Soveny B APPL SC
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. P. Hunt MS, FRCS
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

This study was supported by the National Health and Medical Research Council of Australia.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lambert, J.R., Hansky, J., Soveny, C. et al. Comparative effects of bombesin and porcine gastrin-releasing peptide in the dog. Digest Dis Sci 29, 1036–1040 (1984). https://doi.org/10.1007/BF01311256

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01311256

Keywords

Search

Navigation