Summary
The structural and intracellular proteins of the murine hepatitis viruses MHV-JHM and MHV-A59 were studied by tryptic peptide mapping. The results demonstrated that the virions contained three distinct proteins: the two related chains of the E2 complex, the nucleocapsid protein and the heterogeneous E1 complex. Five distinct virus-specific proteins were synthesized by infected cells. Three of the five intracellular proteins contained tryptic-peptides with properties similar to the three structural proteins. Models describing the evolution of the proteins are proposed. Although the pathogenic properties of MHV-JHM and MHV-A59 differ greatly, the tryptic peptide maps of the corresponding proteins of these MHV strains were remarkably similar.
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Bond, C.W., Anderson, K. & Leibowitz, J.L. Protein synthesis in cells infected by murine hepatitis viruses JHM and A59: Tryptic peptide analysis. Archives of Virology 80, 333–347 (1984). https://doi.org/10.1007/BF01311223
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DOI: https://doi.org/10.1007/BF01311223