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Structural and functional genome organization and life cycle of hepatitis C virus

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Abstract

Modern data on hepatitis C virus genome and polyprotein organization are summarized in this review. The functional roles of structural and nonstructural virus proteins, including their interaction with cellular regulatory proteins and structural cell elements, are described. Special features of the life cycle of the hepatitis C virus (that supplement our knowledge of viral hepatitis C pathogenesis) are presented.

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Authors and Affiliations

  1. St. Petersburg Pasteur Institute, St. Petersburg, 197101, Russia

    O. V. Kalinina

  2. Almazov Northwest Federal Medical Research Center, St. Petersburg, 197341, Russia

    O. V. Kalinina

  3. Federal State Budgetary Scientific Institution Institute of Experimental Medicine, St. Petersburg, 197376, Russia

    A. V. Dmitriev

  4. St. Petersburg State Technological Institute (Technical University), St. Petersburg, 190013, Russia

    A. V. Dmitriev

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  1. O. V. Kalinina
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Correspondence to O. V. Kalinina.

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Original Russian Text © O.V. Kalinina, A.V. Dmitriev, 2015, published in Molekulyarnaya Genetika, Mikrobiologiya i Virusologiya, 2015, No. 2, pp. 9–13.

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Kalinina, O.V., Dmitriev, A.V. Structural and functional genome organization and life cycle of hepatitis C virus. Mol. Genet. Microbiol. Virol. 30, 64–70 (2015). https://doi.org/10.3103/S0891416815020044

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