Summary
An immunoglobulin G avidity assay was used to determine recent and past hantavirus infection in bank voles (Clethrionomys glareolus). Sera of experimentally infected bank voles were studied at different time intervals. The avidity of specific IgG increased over time after infection. This experimental data were used to estimate the time after onset of hantavirus infection in naturally infected bank voles caught in an endemic area. The possibility to discriminate between recently infected animals and animals infected some time ago is important since the proportion of recently infected bank voles represents the intensity of the epizootic which in turn correlates to the risk of humans to contract the disease.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bailey NT (1962) Statistical methods in biology, 2nd edn. Foreign Liter, Moscow
Bernshtein AD, Apekina NS, Gavrilovskaya IN, Myasnikov YuA, Kopylova LF (1990) Characterization of HFRS foci activity in the different periods of epizootic cycle. In: Ryabov VI (ed) Actual problems of tick-borne encephalitis and hemorrhagic fever with renal syndrome studies in their natural foci, vol 2. Izhevsk, Udmurtia, pp 114–117 (in Russian)
Bogdanova SB, Gavrilovskaya IN, Boiko VA, Prokhorova IA, Linev MB, Apekina NS, Gorbachkova EA, Rymalov IV, Bernshtein AD, Chumakov MP (1987) Persisting infection induced by hermorrhagic fever with renal syndrome in bank voles (Clethrionomys glareolus), natural hosts of the virus. Microbiol J 49: 99–106
Chen L-L, Wang Hong X, Gu X-S (1987) Early diagnosis of hemorrhagic fever with renal syndrome by IgM ELISA technique. Clin Med J 100: 402–405
Chumakov MP, Gavrilovskaya IN, Linev MB, Gorbachkova EA, Song G (1987) Serological differentiation of virus strains of hemorrhagic fever with renal syndrome (HFRS) by monoclonal antibodies. Proc Chin Acad Med Sci Peking Union Med Coll 3: 121–124
Demina V, Povalishina T (1970) Reproduction of bank voles in vivarium condition. In: Flint VE (ed) Population structure of mammals species. Moscow State University, pp 133–135 (in Russian)
Gavrilovskaya IN, Apekina NS, Gorbachkova EA, Chumakov MP (1981) Detection by enzyme linked immunosorbent assay of hemorrhagic fever with renal syndrome virus in lung tissue of rodents from European USSR. Lancet 8228: 1050
Gavrilovskaya IN, Apekina NS, Myasnikov YuA, Bernshtein AD, Ryltseva EV, Gorbachkova EA, Chumakov MP (1983) Features of circulation of hemorrhagic fever with renal syndrome (HFRS) virus among small mammals in the European USSR. Arch Virol 75: 313–316
Gavrilovskaya IN, Apekina NS, Bernshtein AD, Demina VT, Okulova NM, Myasnikov YuA, Chumakov MP (1990) Pathogenesis of hemorrhagic fever with renal syndrome virus infection and mode of horizontal transmission of hantavirus in bank voles. Arch Virol [Suppl] 1: 57–62
Groen van der G, Beelaert G (1985) Immunoperoxidase assay for the detection of specific IgG antibodies to Hantaan virus. J Virol Methods 10: 53–58
Hedman K, Seppälä I (1988) Recent rubella virus infection indicated by a low avidity of specific IgG. J Clin Immunol 8: 214–221
Hedman K, Lappalainen M, Seppälä MO, Mäkelä O (1989) Recent primary toxoplasma infection indicated by a low avidity of specific IgG. J Infect Dis 159: 736–740
Hedman K, Vaheri A, Brummer-Korvenkontio M (1991) Rapid diagnosis of hantavirus disease with an IgG-avidity assay. Lancet 338: 1353–1356
Ivanov AP, Tkachenko EA, Petrov VA, Pashkov AJ, Dzagurova TK, Vladimirova TP, Voronkova GM, Groen van der G (1988) Enzyme immuno assay for the detection of virus specific IgG and IgM antibody in patients with hemorrhagic fever with renal syndrome. Arch Virol 100: 1–7
Kangro HO, Manzoor S, Harper DR (1991) Antibody avidity following varicella-zoster virus infections. J Med Virol 36: 100–105
Lee HW, Lee PW, Baeck LJ, Song CK, Seong IW (1981) Intraspecific transmission of Hantaan virus, the etiological agent of Korean hemorrhagic fever, in the rodent Apodemus agrarius. Am J Trop Med Hyg 30: 1106–1112
Lee PW, Amyx HL, Yanagihara R, Gajdusek DK, Goldgaber D, Gibbs CJ (1985) Partial characterization of Prospect Hill virus isolated from meadow voles in the United States. J Infect Dis 4: 826–829
Lee HW, Groen van der G (1989) Hemorrhagic fever with renal syndrome. In: Melnick JL (ed) Progress in Medical Virology, vol 36. Basel, Karger, pp 62–102
Lee HW, Lee PW, Baeck LJ, Chu YK (1990) Geographical distribution of hemorrhagic fever with renal syndrome and hantaviruses. Arch Virol [Suppl] 1: 5–18
Myasnikov YuA, Bashkirev TA, Ozhegova ZE (1980) Epidemiology of hemorrhagic fever with renal syndrome in Middle Volga and Cis-Urals. In: Bashkirev TA (ed) Hemorrhagic fever with renal syndrome in Middle Volga and pre Urals. Institute Pasteur, Leningrad, pp 40–47 (in Russian)
Niklasson B, Tkachenko E, Ivanov A, Groen van der G, Wiger D, Andersen HK, LeDuc J, Kjelsson T, Nyström K (1990) Hemorrhagic fever with renal syndrome evaluation of ELISA for detection of Puumala-virus-specific IgG and IgM. Res Virol 141: 637–648
Settergren B, Juto P, Wadell G (1987) Detection of specific serum immunoglobulin M in nephropathia epidemica (Scandinavian epidemic nephropathy) by a biotin-avidin-amplified immunofluorescence method. J Clin Microbiol 25: 1134–1136
Tanishita O, Takahashi Y, Okuno Y, Tamura M, Asada H, Dantes J, Yamanouchi T, Domae K, Kurata T, Yamanishi K (1986) Persistent infection of rats with hemorrhagic fever with renal syndrome virus and their antibody responses. J Gen Virol 67: 2819–2874
Thomas HIJ, Morgan-Capner P (1991) The use of antibody avidity measurements for the diagnosis of rubella. Med Virol 1: 41–50
Tkachenko EA, Dzagurova TK, Leshchinskaya EV (1982) Serological diagnosis of hemorrhagic fever with renal syndrome in European region of USSR. Lancet 8312: 1407
Tomiyama T, Lee HW (1990) Rapid serodiagnosis of hantavirus infections using high density particle agglutination. Arch Virol [Suppl] 1: 29–33
Yanagihara R, Amyx HL, Gajdusek DC (1985) Experimental infection with Puumala virus, the etiological agent of Nephropathia Epidemica in bank voles (Cletrionomys glareolus). J Virol 55: 34–38
Yanagihara R, Gajdusek DC (1987) Hemorrhagic fever with renal syndrome. Global epidemiology and ecology of hantavirus infections. In: Peterson EM, De la Maza LM (eds) Medical virology, vol 6. Elsevier, New York, pp 171–214
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Gavrilovskaya, I., Apekina, N., Okulova, N. et al. IgG avidity assay for estimation of the time after onset of hantavirus infection in colonized and wild bank voles. Archives of Virology 132, 359–367 (1993). https://doi.org/10.1007/BF01309545
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01309545